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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Nutritional Immunology
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1431910
This article is part of the Research Topic Nutritional Factors in the Development and Prognosis of Inflammatory Bowel Disease (IBD) View all articles

Clinical Implications of Four Different Nutritional Indexes in Patients with IgA nephropathy

Provisionally accepted
Chuyue Qian Chuyue Qian Huimin Li Huimin Li Yue Hou Yue Hou Wanning Wang Wanning Wang Mindan Sun Mindan Sun *
  • Department of Nephrology, First Hospital of Jilin University, Changchun, China

The final, formatted version of the article will be published soon.

    Background: Immunoglobulin A nephropathy (IgAN) is the most prevalent form of chronic kidney disease (CKD), marked by diverse pathological patterns and variable prognostic outcomes.Nutritional indexes are crucial for disease assessment and prognosis prediction. This study investigates associations between nutritional indexes and renal function in patients with IgAN. Methods: A cohort of 736 adults diagnosed with IgAN, who underwent renal biopsy at the First Hospital of Jilin University between January 2010 and October 2022, was examined. Clinical and laboratory data were reviewed, and four nutritional indexes were calculated: controlling nutritional status (CONUT) score, geriatric nutritional risk index (GNRI), body mass index (BMI), and prognostic nutritional index (PNI). Cox-proportional hazard analysis evaluated factors associated with end-stage renal disease (ESRD). Results: Patients with ESRD showed significantly lower GNRI (91.84 vs. 98.94, p < 0.001) and median PNI (41.90 vs. 46.30, p < 0.001), with higher median CONUT score (2.00 vs. 1.00, p = 0.001) compared to those without ESRD. PNI, GNRI, and CONUT scores correlated significantly with C2 in MEST-C classification. Kaplan-Meier analysis indicated increased ESRD probability in individuals with specific thresholds of PNI, GNRI, or CONUT scores. Additionally, GNRI emerged as an independent predictor of ESRD (hazard ratio: 0.963, 95% CI: 0.940 -0.979, p < 0.001), along with platelet count, serum creatinine, eGFR(CKD-EPI), and triglyceride levels. Conclusions: GNRI, NRI, and CONUT scores hold potential in reflecting IgAN severity and predicting ESRD risk. GNRI especially may serve as a valuable tool for identifying high-risk individuals for ESRD in IgAN.

    Keywords: IgA nephropathy (IgAN), nutrition, index, end-stage renal disease, renal pathology

    Received: 13 May 2024; Accepted: 23 Jul 2024.

    Copyright: © 2024 Qian, Li, Hou, Wang and Sun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Mindan Sun, Department of Nephrology, First Hospital of Jilin University, Changchun, China

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