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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Clinical Nutrition
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1431036
This article is part of the Research Topic Systemic Markers of Muscle Loss – Volume II View all articles

Sex differences in association of chest computed tomography defined sarcopenia with cardiovascular risk factors among inpatients

Provisionally accepted
Xin Chen Xin Chen 1Mingyu Zhu Mingyu Zhu 2Jie Cao Jie Cao 2Didi Zuo Didi Zuo 2Zengai Chen Zengai Chen 2Yurong Weng Yurong Weng 2Hua Jiang Hua Jiang 1*Yaomin Hu Yaomin Hu 2*
  • 1 Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China
  • 2 Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

The final, formatted version of the article will be published soon.

    Background: Although sarcopenia has been proposed to be associated with increased risks of cardiovascular diseases (CVD), evidence exploring sex-related differences remains insufficient.We aimed to investigate sex differences in the prevalence of sarcopenia as defined by skeletal muscle area (SMA) in chest CT images and its association with CVD common risk factors.This cross-sectional study included 1340 inpatients from the Geriatric Department of Renji Hospital affiliated to Shanghai Jiaotong University School of Medicine. Age, sex, body mass index (BMI), smoking status, disease history, and clinical parameters were collected.Sarcopenia was determined by the chest CT images with a cut-off value of T12-SMA/height 2 < 25.75 cm 2 /m 2 in male and < 20.16 cm 2 /m 2 in female. Cardiovascular risk was determined using the Framingham risk score (FRS). The association between T12-SMA/height 2 defined sarcopenia and CVD risk factors by sex was evaluated by multivariate logistic regression.The prevalence of T12-SMA/height 2 defined sarcopenia (＜25.75cm 2 /m 2 for male, ＜20.16cm 2 /m 2 for female) was 54.03% overall, 48.09% for male and 63.19% for female. The proportion of male with high CVD risk was higher than that of female. The multivariate analysis model showed that T12-SMA/height 2 defined sarcopenia was independently associated with age (in male only), systolic blood pressure (SBP), cholesterol and high density lipoprotein cholesterol (HDL-C) of the 6 FRS cardiovascular risk indices.Our results indicated that T12SMA/height 2 -defined sarcopenia was more prevalent in male than female. Sarcopenia was associated with higher level of SBP and HDL-C, and lower level of cholesterol. Increasing age had a more significant effect on CVD risk in male.

    Keywords: Sarcopenia, Chest CT, Skeletal muscle area, Cardiovascular diseases risk factors, Hospitalized patients

    Received: 11 May 2024; Accepted: 13 Aug 2024.

    Copyright: © 2024 Chen, Zhu, Cao, Zuo, Chen, Weng, Jiang and Hu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Hua Jiang, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China
    Yaomin Hu, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200000, China

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