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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Nutrition and Microbes
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1430730
This article is part of the Research Topic Unlocking the Nexus of Bioactive Components, Nutrition, and Nutrigenomics in Age-Related Disorders View all 6 articles

Association Between Dietary Magnesium Intake and Pelvic Inflammatory Disease in US Women: A Cross-Sectional Study of NHANES

Provisionally accepted
Zeru Chen Zeru Chen 1,2Zichun Wu Zichun Wu 1,3Yuying Zhang Yuying Zhang 4*
  • 1 Guangzhou Medical University, Guangzhou, China
  • 2 Department of Clinical Medicine, Second Clinical School, Guangzhou Medical University, Guangzhou, China
  • 3 Department of Clinical Medicine, The First Clinical School of Guangzhou Medical University, Guangzhou, China
  • 4 Shenzhen Longhua Maternity and child Healthcare Hospital, Shenzhen, China

The final, formatted version of the article will be published soon.

    Background: Pelvic inflammatory disease (PID) is a common gynecological condition associated with significant morbidity and healthcare costs. Emerging evidence suggests that dietary factors, such as magnesium intake, may play a role in PID risk. However, the relationship between dietary magnesium intake and PID risk remains uncertain. This cross-sectional study aimed to investigate the association between dietary magnesium intake and the risk of PID.Examination Survey (NHANES) 2015-2018. Weighted multivariable logistic regression was used to examine the association between dietary magnesium intake and PID. Restricted cubic spline (RCS) analysis was performed to assess the linear and non-linear associations. Subgroup analyses were performed based on baseline characteristics.Results: A total of 3,034 women aged 20-59 were included in the study. Magnesium intake exhibited a significant association with lower PID risk in weighted multivariable logistic regression. Adjusted odds ratios (ORs) for dietary magnesium intake in quartiles Q2(133.12-214.93 mg/day), Q3 (214.93-287.19 mg/day), and Q4 (above 287.19 mg/day) compared to Q1 (below 133.12 mg/day) were 0.48 (95% CI: 0.28-0.82), 0.64 (95% CI: 0.32-1.27), and 0.40 (95% CI: 0.18-0.88), respectively. Stratified analyses showed that significant association between dietary magnesium intake and PID in older subgroup but not in younger subgroup. Additionally, RCS analyses consistently revealed a linear negative correlation between dietary magnesium intake and PID risk.This study reveals a significant negative correlation between dietary magnesium intake and risk of PID, particularly among older individuals. These findings underscore the importance of dietary factors in gynecological health and highlight the potential role of magnesium supplementation in PID prevention strategies.

    Keywords: Magnesium, Pelvic Inflammatory Disease, national Health and Nutrition Examination Survey (NHANES), Cross-sectional study, Restricted cubic spline (RCS)

    Received: 10 May 2024; Accepted: 22 Jul 2024.

    Copyright: © 2024 Chen, Wu and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yuying Zhang, Shenzhen Longhua Maternity and child Healthcare Hospital, Shenzhen, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.