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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Clinical Nutrition
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1430471

Association between advanced lung cancer inflammation index and chronic kidney disease: A cross-sectional study

Provisionally accepted
Xiaotong Li Xiaotong Li 1Wang Qian Wang Qian 1,2Feng Wu Feng Wu 1Ziyang Ye Ziyang Ye 3YAFENG LI YAFENG LI 1,4,5,6,7*
  • 1 Department of Nephrology, Shanxi Provincial People's Hospital, Taiyuan, China
  • 2 Shanxi Provincial Key Laboratory of Kidney Disease, Taiyuan, China
  • 3 Other, Taiyuan, China
  • 4 Chronic Kidney Disease Medical and Pharmaceutical Basic Research Innovation Center of the Ministry of Education of the People's Republic of China, Taiyuan, China
  • 5 Core Laboratory, Shanxi Provincial People's Hospital (Fifth Hospital), Shanxi Medical University, Taiyuan, China
  • 6 Academy of Microbial Ecology, Shanxi Medical University, Taiyuan, China
  • 7 Other, Hejin, Yuncheng, China

The final, formatted version of the article will be published soon.

    Background: Chronic kidney disease (CKD) is one of the common chronic diseases, and malnutrition and inflammation play a key role in the development of CKD. The advanced lung cancer inflammation index (ALI) is a novel index of nutrition and inflammation, and its association with CKD has not yet been clarified. The aim of this study was to explore the potential association between ALI and CKD. Methods: We conducted a cross-sectional survey using data extracted from the National Health and Nutrition Examination Survey (NHANES, 2003-2018). Weighted multivariate logistic regression was used to assess the association between ALI and CKD, and smoothed curve fitting and threshold effect analyses were used to describe the nonlinear association between ALI and CKD. Subgroup analyses were performed to further assess the influence of other covariates on the relationship between ALI and CKD. Results: A total of 39,469 adult participants were included in the study, of whom 7,204 (18.25%) were diagnosed with CKD. After adjusting for multiple confounders, we found a significant negative correlation between ALI and CKD (OR =0.93; 95%CI, 0.91-0.95; P <0.0001). The risk of CKD tended to decrease with increasing quartiles of ALI. Smoothed curve fitting showed an L-shaped negative correlation between ALI and CKD. Threshold analysis showed a saturation effect of ALI at the inflection point of 55.09. Subgroup analyses and interaction tests showed that this negative association was maintained across age, sex, race, BMI, diabetes, hypertension, cardiovascular disease, and cancer subgroups (P for interaction > 0.05). Conclusions: Our findings suggest a significant correlation between ALI and CKD in the US adult population. However, more large-scale prospective studies are still needed to further confirm our findings.

    Keywords: Advanced lung cancer inflammation index, Chronic Kidney Disease, nutrition, Inflammation, NHANES, Cross-sectional study

    Received: 14 May 2024; Accepted: 25 Sep 2024.

    Copyright: © 2024 Li, Qian, Wu, Ye and LI. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: YAFENG LI, Department of Nephrology, Shanxi Provincial People's Hospital, Taiyuan, China

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