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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Nutrigenomics
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1428648

The Interactions of Spontaneous Abortion, Dietary Intake of Selenium, and Fat Mass and Obesity Associated (FTO) Genotype: A Case-Control Study in Iran

Provisionally accepted
Saeid Doaei Saeid Doaei 1*Narjes Nooriani Narjes Nooriani 2Zahra Saeedirad Zahra Saeedirad 2Soheila Shekari Soheila Shekari 2Sheyda Nami Sheyda Nami 2Zahra Mahmoodi Zahra Mahmoodi 2Khadijeh Abbasi Mobarakeh Khadijeh Abbasi Mobarakeh 2Somayyeh Bararnia Adabi Somayyeh Bararnia Adabi 2Shiva Khodarahmi Shiva Khodarahmi 2Parsa Bahmani Parsa Bahmani 2Marjan Ajami Marjan Ajami 2Maryam Gholamalizadeh Maryam Gholamalizadeh 1
  • 1 Shahid Beheshti University, Tehran, Iran
  • 2 University of Tehran, Tehran, Tehran, Iran

The final, formatted version of the article will be published soon.

    Background: Spontaneous abortion (SA) is reported to be associated with Fat Mass And Obesity-Associated FTO genotype and dietary intake of selenium. This research assessed the potential interactions between the risk of SA, dietary selenium intake, and the FTO rs9939609 polymorphism. Methods: This case-control study encompassed 192 women who experienced SA and 347 control participants. Dietary selenium intake was evaluated using a comprehensive food frequency questionnaire (FFQ) and Nutritionist IV software. The FTO gene was genotyped for rs9939609 polymorphism. Result: The findings showed that there were no significant variations in the case and control groups' dietary selenium intake. A lower selenium intake was inversely associated with SA only among individuals with the TT genotype of the FTO gene (β=-0.19, P=0.04). The results remained unchanged when age, BMI, physical activity, smoking, alcohol consumption, and calorie intake were taken into account. Conclusion: A link may exist between selenium consumption and SA, especially in individuals with the TT genotype in the FTO gene. These findings underline the influence of genetic factors on how dietary intake impacts SA. Further investigation is required to validate these conclusions

    Keywords: spontaneous abortion, Abortion, Diet, Selenium, FTO gene

    Received: 06 May 2024; Accepted: 26 Nov 2024.

    Copyright: © 2024 Doaei, Nooriani, Saeedirad, Shekari, Nami, Mahmoodi, Abbasi Mobarakeh, Adabi, Khodarahmi, Bahmani, Ajami and Gholamalizadeh. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Saeid Doaei, Shahid Beheshti University, Tehran, Iran

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.