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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Clinical Nutrition
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1428445
This article is part of the Research Topic Optimizing Hydration: Advances in Understanding, Assessment, and Promotion View all 6 articles

Effect of tea consumption on the development of hypertension, diabetes, and obesity: A bidirectional two-sample Mendelian randomization analysis

Provisionally accepted
Xueying Li Xueying Li 1Congcong Zhang Congcong Zhang 2Yihui Weng Yihui Weng 3Weiming Yu Weiming Yu 3Xianlei Cai Xianlei Cai 3*
  • 1 Ningbo First Hospital, Ningbo, Zhejiang Province, China
  • 2 Ningbo University, Ningbo, Zhejiang Province, China
  • 3 Ningbo Medical Centre Lihuili Hospital, Ningbo, Zhejiang Province, China

The final, formatted version of the article will be published soon.

    The effect of tea consumption on conditions such as hypertension, diabetes, and obesity has attracted significant global interest. However, the results of various studies on this topic have been mixed and somewhat contentious. Therefore, we conducted a Mendelian randomization (MR) analysis to investigate the causal relationships between tea consumption and the aforementioned health conditions.A bidirectional two-sample MR analysis was used to systematically explores the associations between tea consumption and hypertension, diabetes, and obesity. MR-Egger regression, weighted median, inverse variance weighted, and weighted mode methods were used to evaluate the potential causal associations. Leave-one-out sensitivity test was used to check the robustness of the IVW estimates.MR analysis indicated that genetically predicted tea consumption is associated with a protective effect against hypertension, with an odds ratio (OR) of 0.78 and a 95% confidence interval (CI) ranging from 0.64 to 0.95. Additionally, tea consumption appeared to have a potential protective effect on type 2 diabetes and obesity related to excessive calorie intake, influenced by specific single nucleotide polymorphisms (SNPs), namely "rs57462170" and "rs17685." No causal link was observed between the consumption of green or herbal tea and hypertension, diabetes, or obesity. However, there was a marginal negative association between type 2 diabetes and tea consumption and (OR=0.99; 95% CI: 0.97-1.00) and a significant negative correlation between obesity due to excessive calorie intake and green tea consumption (OR=0.35; 95% CI: 0.16-0.78).This study demonstrates a protective causal relationship between the consumption of tea (including black and green teas) and reduced risk of hypertension. Furthermore, our results suggest that tea intake may also have a protective effect on type 2 diabetes and obesity. The results recommend further research to verify or refine these findings.

    Keywords: tea consumption, Hypertension, diabetes, Obesity, Mendelian randomization

    Received: 06 May 2024; Accepted: 21 Oct 2024.

    Copyright: © 2024 Li, Zhang, Weng, Yu and Cai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Xianlei Cai, Ningbo Medical Centre Lihuili Hospital, Ningbo, 315010, Zhejiang Province, China

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