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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Nutrition, Psychology and Brain Health
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1427121
This article is part of the Research Topic Nutritional Toxicity: Physiology, Nutrition, and Human Health View all 11 articles

Platycodon grandiflorum Exhibits Anti-Neuroinflammatory Potential against Beta-Amyloid-induced Toxicity in Microglia Cells

Provisionally accepted
Yun-Jeong Ji Yun-Jeong Ji Min H. Kang Min H. Kang *Geum-Soog Kim Geum-Soog Kim *Hyung D. Kim Hyung D. Kim *Gwi Y. Jang Gwi Y. Jang *
  • National Institute of Horticultural and Herbal Science, Rural Development Administration (South Korea), Jeollabuk-do, Republic of Korea

The final, formatted version of the article will be published soon.

    Background/objectives: Platycodon grandiflorum (PG) is used in traditional oriental medicine to treat several ailments. Methods: The study investigated the anti-inflammatory and neuroprotective effects of PGW (P. grandiflorum) extract in Aβ25-35-induced inflammation in BV2 microglia cells. Result: PGW demonstrated significant inhibition of nitric oxide (NO) production, with reductions of 30.4%, 36.7%, and 61.2% at concentrations of 50, 100, and 200 μg/mL, respectively. Moreover, PGW effectively suppressed the production of pro-inflammatory cytokines IL-1β and IL-6 and exhibited significant inhibitory activity against TNF-α at 200 μg/mL. Furthermore, PGW treatment mitigated apoptosis in Aβ-induced BV2 cells by modulating the mitochondrial apoptosis pathway, regulating Bcl-2 family protein synthesis, and inhibiting caspase activation. Mechanistically, PGW attenuated the activation of the MAPK (JNK, ERK, p38) pathway induced by Aβ, showing a concentration-dependent decrease in phosphorylation levels of these proteins. Additionally, PGW inhibited the NF-κB pathway activation by reducing the phosphorylation levels of p65 and IκBα in a concentration-dependent manner. Conclusion: PGW demonstrated anti-inflammatory and neuroprotective effects in Aβinduced neuronal cells, suggesting its potential as a therapeutic agent for neuroinflammatory associated with neurodegenerative diseases.

    Keywords: Platycodon grandiflorum, Amyloid beta, Microglia cells, Neuro-inflammatory 1, NF-κB pathway

    Received: 07 May 2024; Accepted: 29 Jul 2024.

    Copyright: © 2024 Ji, Kang, Kim, Kim and Jang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Min H. Kang, National Institute of Horticultural and Herbal Science, Rural Development Administration (South Korea), Jeollabuk-do, 55365, Republic of Korea
    Geum-Soog Kim, National Institute of Horticultural and Herbal Science, Rural Development Administration (South Korea), Jeollabuk-do, 55365, Republic of Korea
    Hyung D. Kim, National Institute of Horticultural and Herbal Science, Rural Development Administration (South Korea), Jeollabuk-do, 55365, Republic of Korea
    Gwi Y. Jang, National Institute of Horticultural and Herbal Science, Rural Development Administration (South Korea), Jeollabuk-do, 55365, Republic of Korea

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.