Skip to main content

REVIEW article

Front. Nutr.
Sec. Nutrition, Psychology and Brain Health
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1425839
This article is part of the Research Topic Intervention Effects of Food-derived Polyphenols and Bioactive Peptides on Chronic Inflammation View all 12 articles

Neurodegenerative diseases and catechins: (-)-Epigallocatechin-3-gallate is a modulator of chronic neuroinflammation and oxidative stress

Provisionally accepted
Siying Li Siying Li 1,2Zaoyi Wang Zaoyi Wang 2Gang Liu Gang Liu 2Meixia Chen Meixia Chen 1*
  • 1 Yuhuan People's Hospital, Taizhou, China
  • 2 Hunan Agricultural University, Changsha, China

The final, formatted version of the article will be published soon.

    Catechins, a class of phytochemicals found in various fruits and tea leaves, have garnered attention for their diverse health-promoting properties, including their potential in combating neurodegenerative diseases. Among these catechins, (-)-Epigallocatechin-3-gallate (EGCG), the most abundant polyphenol in green tea, has emerged as a promising therapeutic agent due to its potent antioxidant and anti-inflammatory effects. Chronic neuroinflammation and oxidative stress are key pathological mechanisms in neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD). EGCG has neuroprotective efficacy due to scavenging free radicals, reducing oxidative stress and attenuating neuroinflammatory processes. This review discusses the molecular mechanisms of EGCG's anti-oxidative stress and chronic neuroinflammation, emphasizing its effects on autoimmune responses, neuroimmune system interactions, and focusing on the related effects on AD and PD. By elucidating EGCG's mechanisms of action and its impact on neurodegenerative processes, this review underscores the potential of EGCG as a therapeutic intervention for AD, PD, and possibly other neurodegenerative diseases. Overall, EGCG emerges as a promising natural compound for combating chronic neuroinflammation and oxidative stress, offering novel avenues for neuroprotective strategies in the treatment of neurodegenerative disorders.

    Keywords: catechins, (-)-epigallocatechin-3-gallate, Neurodegenerative Diseases, Alzheimer's disease, Parkinson's disease

    Received: 23 May 2024; Accepted: 11 Jul 2024.

    Copyright: © 2024 Li, Wang, Liu and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Meixia Chen, Yuhuan People's Hospital, Taizhou, 317602, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.