Skip to main content

ORIGINAL RESEARCH article

Front. Nutr.
Sec. Nutrition, Psychology and Brain Health
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1424614
This article is part of the Research Topic Resistant Starch: Advances and Applications in Nutrition for Disease Prevention View all 8 articles

The Associations of Dietary Manganese, Iron, Copper, Zinc, Selenium and Magnesium With Cognitive Outcomes in Chinese Adults: A Cross Sectional Study in Shanghai

Provisionally accepted
Yujie Chen Yujie Chen 1Zhuo Sun Zhuo Sun 2*Yali Zhang Yali Zhang 1*Ren Zhou Ren Zhou 3Lin Xingyu Lin Xingyu 1Yuewen Du Yuewen Du 1*Jiayi Xu Jiayi Xu 1*Qi Xu Qi Xu 1*Jiajie Zang Jiajie Zang 2*
  • 1 Shanghai University of Traditional Chinese Medicine, Shanghai, China
  • 2 Shanghai Municipal Center for Disease Control and Prevention (SCDC), Shanghai, China
  • 3 Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, Shanghai, China

The final, formatted version of the article will be published soon.

    The role of individual nutrients including vitamins and minerals in cognitive function gained increasing attention in recent years. With regard to the association between dietary minerals and cognitive function, the results of human studies are inconclusive. The objective of this study was to explore the association between mineral intake and cognitive function using the data from Shanghai Health and Nutrition Survey (SHNS) in 2018. In total, 835 adults were included in a cross-sectional study, and completed a three-day dietary record to estimate their average daily intake of minerals. Mini-Mental State Examination(MMSE) was used for the assessment of cognitive function, and logistic regression analyses were performed on participants to examine the association between dietary mineral intake and cognitive performance. The participants were divided into tertiles according to their mineral intake. Participants in the second and third tertile of the dietary copper intake had lower rates of low MMSE scores compared to those in the lowest tertile. We found the adjusted OR and 95%CI values were 0.44 (0.21 -0.89) and 0.40 (0.16 -0.94), respectively. Participants in the second tertile of dietary magnesium intake showed a trend of lower rates of low MMSE score compared to those in the lowest tertile (p=0.06). The adjusted OR and 95%CI values were 0.35 (0.16 -0.72). No significant association were observed between any of the other minerals including iron, zinc, selenium and manganese and cognitive function. Our findings suggest that dietary intake of copper and magnesium may 2 have a protective effect on cognitive performance in elderly over 60 years old. To prevent cognitive decline, elderly should get recommended amounts of copper and magnesium from diet or supplements.

    Keywords: Dietary minerals, Low MMSE scores, Cognitive Function, Dietary copper, dietary magnesium

    Received: 28 Apr 2024; Accepted: 13 Nov 2024.

    Copyright: © 2024 Chen, Sun, Zhang, Zhou, Xingyu, Du, Xu, Xu and Zang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Zhuo Sun, Shanghai Municipal Center for Disease Control and Prevention (SCDC), Shanghai, China
    Yali Zhang, Shanghai University of Traditional Chinese Medicine, Shanghai, China
    Yuewen Du, Shanghai University of Traditional Chinese Medicine, Shanghai, China
    Jiayi Xu, Shanghai University of Traditional Chinese Medicine, Shanghai, China
    Qi Xu, Shanghai University of Traditional Chinese Medicine, Shanghai, China
    Jiajie Zang, Shanghai Municipal Center for Disease Control and Prevention (SCDC), Shanghai, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.