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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Nutrition and Metabolism
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1424286
This article is part of the Research Topic Diet, Trace Elements, and Gut Microbiota in Bone and Cartilage Diseases View all articles

Causal link between metabolic related factors and osteoarthritis: A Mendelian randomization investigation

Provisionally accepted
Kai Li Kai Li 1Yan Leng Yan Leng 1Di Lei Di Lei 1Zhang Haojie Zhang Haojie 1Minghui Ding Minghui Ding 1*Wai L. Lo Wai L. Lo 1,2*
  • 1 Department of Rehabilitation Medicine, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
  • 2 Guangdong Engineering and Technology Research Centre for Rehabilitation Medicine and Translation, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China

The final, formatted version of the article will be published soon.

    Background: Metabolic syndrome (MetS) is significantly associated with osteoarthritis (OA), especially in MetS patients with blood glucose abnormalities, such as elevated fasting blood glucose (FG), which may increase OA risk. Dietary modifications, especially the intake of polyunsaturated fatty acids (PUFAs), are regarded as a potential means of preventing MetS and its complications. However, regarding the effects of FG, Omega-3s, and Omega-6s on OA, the research conclusions are conflicting, which is attributed to the complexity of the pathogenesis of OA. Therefore, it is imperative to thoroughly evaluate multiple factors to fully understand their role in OA, which needs further exploration and clarification. Conclusion: The MR investigation showed a protective effect of FG on KOA development but no causal relationship between FG and HOA. No causal effect of Omega-3s and Omega-6s on HOA and KOA was observed. Shared genetic overlaps might also exist between BMI and age, SHBG and PUFAs for OA development. This finding offers a novel insight into the treatment and prevention of KOA from glucose metabolism perspective. The FG cutoff value should be explored in the future, and consideration should be given to demonstrating the study in populations other than Europeans.

    Keywords: Osteoarthritis, Omega-3 fatty Acids, omega-6 fatty acids, Mendelian randomization, Genome-Wide Association Study, Fasting glucose

    Received: 27 Apr 2024; Accepted: 22 Jul 2024.

    Copyright: © 2024 Li, Leng, Lei, Haojie, Ding and Lo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Minghui Ding, Department of Rehabilitation Medicine, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China
    Wai L. Lo, Department of Rehabilitation Medicine, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.