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CLINICAL TRIAL article
Front. Nutr.
Sec. Nutrition and Microbes
Volume 11 - 2024 |
doi: 10.3389/fnut.2024.1423724
Integrative metagenomic and lipidomic analyses reveal alterations in children with obesity and after lifestyle intervention
Provisionally accepted- 1 Department of Pediatrics, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
- 2 Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, Henan Province, China
Background: Despite emerging evidence linking alterations in gut microbiota to childhood obesity, the metabolic mechanisms linking gut microbiota to the lipid profile during childhood obesity and weight loss remain poorly understood.In this study, children with obesity were treated with lifestyle weight loss therapy. Metagenomics association studies and serum untargeted lipidomics analyses were performed in children with obesity and healthy controls before and after weight loss.We identified alterations in gut microbiota associated with childhood obesity, as well as variations in circulating metabolite concentrations. Children with obesity showed significant decreases in the levels of s-Rothia_kristinae and s-Enterobacter_roggenkampii, alongsige elevated levels of s-Clostridiales_bacterium_Marseille-P5551. Following weight loss, the levels of s-Streptococcus_infantarius and s-Leuconostoc_citreum increased by factors of 3.354 and 1.505, respectively, in comparison to their pre-weight loss levels. Correlation analyses indicated a significant positive relationship between ChE(2:0) levels and both with s-Lachnospiraceae_bacterium_TF09-5 and fasting glucose levels. CoQ8 levels were significantly negatively correlated with s-Rothia_kristinae and HOMA-IR.We linked altered gut microbiota and serum lipid levels in children with obesity to clinical indicators, indicating a potential impact on glucose metabolism via lipids. This study contributes to understanding the mechanistic relationship between altered gut microbiota and childhood obesity and weight loss, suggesting gut microbiome as a promising target for intervention.
Keywords: childhood, Obesity, Metagenomics, lipidomic, Weight Loss
Received: 26 Apr 2024; Accepted: 26 Aug 2024.
Copyright: © 2024 Yin, Liu, Li, Li, Liu, Qin, Zhang, Sun and Xiao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yanfeng Xiao, Department of Pediatrics, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, China
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