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SYSTEMATIC REVIEW article

Front. Nutr.
Sec. Clinical Nutrition
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1422604

Refeeding syndrome in critically ill patients: a systematic review and metaanalysis

Provisionally accepted
Qian Zhang Qian Zhang 1Rui Liu Rui Liu 2Wei Zheng Wei Zheng 3Hua Liu Hua Liu 4Chaofeng Fan Chaofeng Fan 5*
  • 1 Lung Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
  • 2 Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, China
  • 3 Department of Nursing, Hospital of China Wuye Group Co, Chengdu, China
  • 4 Department of Neurosurgery, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu, China
  • 5 Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China

The final, formatted version of the article will be published soon.

    Background: Refeeding syndrome (RFS) is a potentially fatal metabolic complication observed in critically ill patients undergoing nutritional rehabilitation. Despite its clinical significance, the prevalence and impact of RFS in this population remain poorly characterized.Objectives: This systematic review and meta-analysis aimed to determine the prevalence of RFS in critically ill patients, assess associated mortality rates, and evaluate its impact on hospitalization duration and healthcare costs.We conducted a comprehensive search of Embase, MEDLINE, Cochrane Central Register of Controlled Trials, CINAHL, Web of Science, Scopus, and CNKI, as well as the gray literature in December 2023, and updated it in June 2024, to identify relevant studies. We will assess the quality of studies using the Newcastle-Ottawa Scale (NOS) checklist. Two reviewers will screen all retrieved articles, conduct data extraction, and critically appraise all identified studies. Data analysis will be performed using Revman statistical software. Only qualitative synthesis will be performed for studies that exhibit excessive heterogeneity.Results: A total of 15 studies met the inclusion criteria, encompassing 6396 critically ill patients.Descriptive assessment showed that the prevalence of RFS varied considerably between ICUs, with the widest range observed in comprehensive ICUs, ranging from 27% to 88%. There was significant heterogeneity in the prevalence of RFS even among studies using the same diagnostic criteria. The 1-month and 6-month mortality among patients with RFS was significantly higher compared to

    Keywords: Refeeding Syndrome, critically ill patients, Systematic review, Meta-analysis, Prevalence, Mortality

    Received: 24 Apr 2024; Accepted: 19 Jul 2024.

    Copyright: © 2024 Zhang, Liu, Zheng, Liu and Fan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Chaofeng Fan, Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.