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REVIEW article

Front. Nutr.
Sec. Nutrition and Metabolism
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1419229
This article is part of the Research Topic Dietary Protein for Human Health View all 16 articles

Critical Variables Regulating Age-related Anabolic Responses to Protein Nutrition in Skeletal Muscle

Provisionally accepted
Colleen S. Deane Colleen S. Deane 1Jake Cox Jake Cox 2Philip J. Atherton Philip J. Atherton 2*
  • 1 University of Southampton, Southampton, Hampshire, United Kingdom
  • 2 University of Nottingham, Nottingham, England, United Kingdom

The final, formatted version of the article will be published soon.

    Protein nutrition is critical for the maintenance of skeletal muscle mass across the lifecourse and for the growth of muscle in response to resistance exercise – both acting via the stimulation of protein synthesis. The transient anabolic response to protein feeding may vary in magnitude and duration, depending on e.g., timing, dose, amino acid composition and delivery mode, which are in turn influenced by physical activity and age. This review aims to: i) summarise the fundamental metabolic responses of muscle to protein feeding, ii) discuss key variables regulating muscle anabolic responses to protein feeding, and iii) explore how these variables can be optimized for muscle anabolism in response to physical activity and ageing.

    Keywords: protein, nutrition, Muscle, Ageing, Exercise

    Received: 17 Apr 2024; Accepted: 23 Jul 2024.

    Copyright: © 2024 Deane, Cox and Atherton. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Philip J. Atherton, University of Nottingham, Nottingham, NG7 2RD, England, United Kingdom

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.