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REVIEW article

Front. Nutr.
Sec. Sport and Exercise Nutrition
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1418778
This article is part of the Research Topic Preventing Sarcopenia and Promoting Musculoskeletal Health in Middle-Aged Adults: The Role of Exercise and Nutrition View all 3 articles

Gut-muscle axis mechanism of exercise prevention of sarcopenia

Provisionally accepted
Tao Li Tao Li Danyang Yin Danyang Yin Rengfei Shi Rengfei Shi *
  • Shanghai University of Sport, Shanghai, China

The final, formatted version of the article will be published soon.

    Sarcopenia refers to an age-related systemic skeletal muscle disorder, characterized by loss of muscle mass and weakening of muscle strength. Gut microbiota can affect skeletal muscle through a variety of mechanisms. Gut microbiota present distinct features among the elderly and sarcopenia patients, including the decrease of microbial diversity, which might be associated with the quality and function of the skeletal muscle. There might be a gut-muscle axis, gut microbiota and skeletal muscle may affect each other bi-directionally. Skeletal muscle can affect the biodiversity of gut microbiota, and the latter can in turn affect the anabolism of skeletal muscle. This review examines recent studies exploring the relationship between gut microbiota and skeletal muscle, summarizes the effects of exercise on gut microbiota, and discusses the possible mechanisms of the gut-muscle axis.

    Keywords: Sarcopenia, Gut Microbiota, Gut-muscle axis, Exercise, SCFA

    Received: 17 Apr 2024; Accepted: 22 Jul 2024.

    Copyright: © 2024 Li, Yin and Shi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Rengfei Shi, Shanghai University of Sport, Shanghai, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.