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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Clinical Nutrition
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1418159

Exploring the Association Between Dietary Vitamin A and Coronary Artery Disease Risk in Men and Women: Findings from a US Population Study

Provisionally accepted
Zhijian Wu Zhijian Wu 1Weichang Yang Weichang Yang 1*Haiyang Fang Haiyang Fang 1*Yi Chen Yi Chen 1*Yanqing Wu Yanqing Wu 1,2*Ren Gong Ren Gong 1*
  • 1 Second Affiliated Hospital of Nanchang University, Nanchang, China
  • 2 Cardiovascular and Cerebrovascular Disease Hospital affiliated with Nanchang University, Nanchang, Jiangxi Province, China

The final, formatted version of the article will be published soon.

    Coronary artery disease (CAD) is an important public health problem with negative impacts on individual health and socioeconomics. Studies on the relationship of dietary vitamin A (DVA) to CAD are limited and conflicting. The purpose of this study was to investigate the relationship between DVA and the prevalence of CAD in U.S. adults, with particular interest in sex differences. Data from 26,449 NHANES participants were used for analysis. The association of DVA with the prevalence of CAD was investigated utilizing multivariate logistic regression models and fitted smoothed curves, and interaction tests were performed to explore potential modifiers. This study included 12748 males and 13701 females aged 50.34 ± 17.54 years. Overall, adjusted DVA was linearly negatively correlated with CAD (per natural ln (DVA) increment: OR 0.91, 95%CI 0.83-0.99). Multivariate regression analysis showed that among female participants, each natural increment of ln DVA was associated with a 22% reduction in CAD prevalence (OR 0.78, 95% CI 0.68-0.89). However, there was no significant correlation in male participants (P for interaction <0.001). DVA was negatively associated with the prevalence of CAD, and further analysis revealed an interaction between DVA and sex in terms of CAD prevalence.

    Keywords: Coronary Artery Disease, dietary vitamin A, Sex-difference, Cross-sectional study, Interaction

    Received: 16 Apr 2024; Accepted: 01 Oct 2024.

    Copyright: © 2024 Wu, Yang, Fang, Chen, Wu and Gong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Weichang Yang, Second Affiliated Hospital of Nanchang University, Nanchang, China
    Haiyang Fang, Second Affiliated Hospital of Nanchang University, Nanchang, China
    Yi Chen, Second Affiliated Hospital of Nanchang University, Nanchang, China
    Yanqing Wu, Second Affiliated Hospital of Nanchang University, Nanchang, China
    Ren Gong, Second Affiliated Hospital of Nanchang University, Nanchang, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.