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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Clinical Nutrition
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1414124
This article is part of the Research Topic Nutritional Factors in the Development and Prognosis of Inflammatory Bowel Disease (IBD) View all 4 articles

The simplified GLIM criteria for assessment of malnutrition and its correlation with clinical outcomes in Crohn's disease patients

Provisionally accepted
Xiaomei Song Xiaomei Song 1,2,3Xiaoxin Zhou Xiaoxin Zhou 1,2Hao Wang Hao Wang 3Hong Guo Hong Guo 1Jian Yang Jian Yang 1,2*
  • 1 Research Center for Metabolic and Cardiovascular Diseases, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China
  • 2 Department of Clinical Nutrition, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China
  • 3 Department of Gastroenterology and Infectious Diseases, Chongqing General Hospital, Chongqing, China

The final, formatted version of the article will be published soon.

    Objective: Patients with Crohn's disease (CD) commonly experience malnutrition.The Global Leadership Initiative on Malnutrition (GLIM) criteria, a novel approach to assessing malnutrition, has been validated in some diseases. However, there are limited studies in CD patients. This study aimed to investigate the applicability and effectiveness of the simplified GLIM criteria for evaluating the nutritional status of patients with Crohn's disease. Additionally, it sought to evaluate the correlation between malnutrition defined by simplified GLIM and clinical outcomes.Methods: A retrospective cohort study was conducted with 386 patients with CD.Data were extracted from the medical records, including demographic and clinical characteristics. All patients were evaluated using the simplified GLIM criteria. The prevalence of malnutrition was reported and the relationship between malnutrition and clinical outcome was analyzed.The prevalence of malnutrition among patients with CD was 73.6%, with 36.5% classified as moderate malnutrition and 37.0% classified as severe malnutrition.The malnourished group had significantly higher Crohn's Disease Activity Index (CDAI) scores compared to the non-malnourished group (P<0.001). Furthermore, the malnutrition group exhibited significantly lower levels of specific nutritional indicators, including hemoglobin (P=0.040), albumin (P=0.015), and prealbumin (P=0.021). The median duration of follow-up in the cohort was 15.2 weeks. The results indicated that malnutrition, as assessed by simplified GLIM, independently influenced endoscopic remission (P=0.033). Additionally, the duration of disease (P=0.021), C-reactive protein (P=0.014) and prealbumin (P=0.014) were independent factors influencing endoscopic remission in patients with CD.Conclusions: Malnutrition identified using the simplified GLIM criteria is associated with age, CDAI, behavior, hemoglobin, and albumin, providing prognostic value for endoscopic remission in CD patients.

    Keywords: Crohn's disease, GLIM criteria, Malnutrition, clinical outcome, endoscopic remission

    Received: 08 Apr 2024; Accepted: 17 Dec 2024.

    Copyright: © 2024 Song, Zhou, Wang, Guo and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jian Yang, Research Center for Metabolic and Cardiovascular Diseases, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.