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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Clinical Nutrition
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1413091

The association between concentration of plasma trans fatty acids and rheumatoid arthritis: a cross-sectional study using NHANES 1999-2000,2009-2010 among US adult

Provisionally accepted
Tanjian Li Tanjian Li 1Na Jiang Na Jiang 2Xin Liang Xin Liang 1Xinya Li Xinya Li 1Yaqin Li Yaqin Li 1Yuting Huang Yuting Huang 1Yu Wang Yu Wang 3*
  • 1 Jinan University, Guangzhou, China
  • 2 Binzhou Polytechnic, Binzhou, Shandong Province, China
  • 3 Guangzhou Overseas Chinese Hospital, Jinan University, Guangzhou, China

The final, formatted version of the article will be published soon.

    Objective While earlier research has indicated that trans fatty acids (TFAs) are detrimental to cardiovascular health as well as other conditions, the purpose of this study is to look into any possible connections between trans fatty acids and rheumatoid arthritis (RA). Methods 4The NHANES database provided the data for this study, covering two periods: 1999-2000 and 2009-2010. The correlation between plasma TFAs (linolelaidic acid, vaccenic acid, palmitelaidic acid, elaidic acid) and RA was examined using weighted univariate and multivariate regression analyses as well as analysis of subgroups. Additionally, this study employs restricted cubic spline curves to investigate the nonlinear relationship between them. Result This study included 2938 patients, of whom 222 (7.56%) had RA. Multivariate logistic regression analysis showed that levels of linolelaidic acid were linked to a higher risk of RA (odds ratio=1.39, 95% confidence interval=1.05-1.85, P=0.025) after accounting for all other variables. No significant effect on this association was found in interaction tests. Linolelaidic acid and RA were demonstrated to have a linear association in the limited cubic spline regression model. For RA, linolelaidic acid exhibits a critical value of 0.98. Conclusion Findings that point to a possible link between elevated plasma TFAs levels and an increased risk of RA offer fresh perspectives on RA prevention through dietary interventions.

    Keywords: NHANES, Trans Fatty Acids, Linolelaidic acid, Rheumatoid arthritis, Crosssectional study

    Received: 06 Apr 2024; Accepted: 25 Nov 2024.

    Copyright: © 2024 Li, Jiang, Liang, Li, Li, Huang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yu Wang, Guangzhou Overseas Chinese Hospital, Jinan University, Guangzhou, 510630, China

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