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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Nutrigenomics
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1410811
This article is part of the Research Topic Nutrients, Stress Response, and Human Health View all 4 articles

The interaction between polyphenol intake and genes (MC4r, Cav-1, and Cry1) related to body homeostasis and cardiometabolic risk factors in overweight and obese women: A cross-sectional study

Provisionally accepted
zahra roumi zahra roumi 1Atieh Mirzababaei Atieh Mirzababaei 2Faezeh Abaj Faezeh Abaj 3soheila daveneghi soheila daveneghi 4yasaman aali yasaman aali 2Khadijeh Mirzaei Khadijeh Mirzaei 2*
  • 1 Science and Research Branch, Islamic Azad University, Tehran, Tehran, Iran
  • 2 Tehran University of Medical Sciences, Tehran, Tehran, Iran
  • 3 Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Clayton, Victoria, Australia
  • 4 Tabriz University of Medical Sciences, Tabriz, Iran

The final, formatted version of the article will be published soon.

    Background Cardiovascular disease (CVD), which is an important global health challenge, is expanding. One of the main factors in the occurrence of CVD is a high genetic risk . The interaction between genetic risk in CVD and nutrition is debatable. Polyphenols are one of the important dietary components that may have a protective role in people who have a high genetic risk score (GRS) for cardiometabolic risk factors. This study, conducted in overweight and obese women, examines the interaction between polyphenol intake and specific genes (MC4r, Cav-1, and Cry1) related to maintaining body balance and their interaction with cardiometabolic risk factors.Methods This cross-sectional study included 391 women who were overweight or obese, aged 18 to 48 years, with a body mass index (BMI) between 25 and 40 kg/m2. Body composition was measured using the InBody 770 scanner. Total dietary polyphenol intake (TDPI) was assessed with a validated 147-item food frequency questionnaire (FFQ), and polyphenol intakes were determined using the Phenol-Explorer database. Serum samples underwent biochemical tests. The Genetic Risk Score (GRS) was calculated based on the risk alleles of three genes: MC4r, Cav-1, and Cry1.The mean ± standard deviation (SD) age and BMI of women were 36.67 (9.1) years and 30.98 (3.9) kg/m 2 respectively. The high GRS and high TDPI group had a significant negative interaction with fasting blood glucose (FBS) (P= 0.01). Individuals who had a high GRS and a high phenolic acid intake were found to have a significant negative interaction with Triglyceride [1] (P= 0.04). Similarly, individuals with high GRS and a high intake of flavonoids had a significant negative interaction with TG (P<0.01) and a significant positive interaction with High-density lipoprotein (HDL) (P= 0.01) in the adjusted model.According to our findings, those with a high GRS may have a protective effect on cardiometabolic risk factors by consuming high amounts of polyphenols. Further studies will be necessary in the future to validate this association.

    Keywords: Cardiometabolic risk factors, Genetic risk score, Homeostasis, Obesity, Polyphenols

    Received: 23 Apr 2024; Accepted: 10 Jul 2024.

    Copyright: © 2024 roumi, Mirzababaei, Abaj, daveneghi, aali and Mirzaei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Khadijeh Mirzaei, Tehran University of Medical Sciences, Tehran, 1417863181, Tehran, Iran

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.