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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Nutrigenomics
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1409578

Vitamin C intake and osteoarthritis: findings of NHANES 2003-2018 and Mendelian randomization study

Provisionally accepted
Hongjie Zhang Hongjie Zhang 1Xuan Jiang Xuan Jiang 2Lei Bai Lei Bai 3Jiahui Chen Jiahui Chen 2Wei Luo Wei Luo 4Jianxiong Ma Jianxiong Ma 4Xinlong Ma Xinlong Ma 4*
  • 1 Dehong People's Hospital, Mangshi, China
  • 2 Tianjin Medical University, Tianjin, Tianjin Municipality, China
  • 3 Tianjin University of Traditional Chinese Medicine, Tianjin, China
  • 4 Tianjin Hospital, Tianjin Orthopedic Research Institute, Tianjin, China

The final, formatted version of the article will be published soon.

    Background The role of vitamin C in osteoarthritis (OA) is still a subject of debate. Our aim was to combine the National Health and Nutrition Examination Survey (NHANES) and MR studies to explore the relationship between Vitamin C intake and OA. Methods Clinical information on participants during NHANES 2003-2018 was collected and the relationship between vitamin C intake and OA risk was assessed using logistic regression modelling. In MR analyses, three methods were used to explore the causality of vitamin C intake with OA. Sensitivity analysis to verify the stability of the MR study. Results The cross-sectional study included a total of 31,527 participants, categorizing them into low (< 30.2 mg), medium (30.2-93.0 mg) and high (>93.0 mg) level groups based on their vitamin C intake levels. Logistic regression models showed that vitamin C intake was not associated with OA risk (p>0.05). Inverse-variance weighted (IVW) method of MR study showed no causality between vitamin C intake and OA (OR= 0.993, 95% CI: 0.901~1.095, p = 0.882). Sensitivity analysis indicated that the MR study was reliable Conclusions Our cross-sectional and MR studies showed that vitamin C intake was not associated with OA risk. More researches are needed in the future to investigate the link between vitamin C and OA.

    Keywords: NHANES, Vitamin C intake, Osteoarthritis, Mendelian randomization, nutrition

    Received: 30 Mar 2024; Accepted: 15 Oct 2024.

    Copyright: © 2024 Zhang, Jiang, Bai, Chen, Luo, Ma and Ma. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Xinlong Ma, Tianjin Hospital, Tianjin Orthopedic Research Institute, Tianjin, China

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