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REVIEW article

Front. Nutr.
Sec. Nutrigenomics
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1409142
This article is part of the Research Topic Diet, Nutritional Status, and Their Interaction with Genetics/Epigenetics in Different Stages of Carcinogenesis View all 4 articles

Autophagy and Nutrigenomics: A Winning Team Against Chronic Disease and Tumors

Provisionally accepted
Fabio Caradonna Fabio Caradonna Roberto Chiarelli Roberto Chiarelli *Flores Naselli Flores Naselli
  • Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Palermo, Sicily, Italy

The final, formatted version of the article will be published soon.

    Autophagy, a vital cell process, has garnered attention for its role in various diseases and potential therapeutic interventions. Dysregulation of autophagy contributes to conditions such as metabolic diseases, neurodegenerative disorders, and cancer. In diseases such as diabetes, autophagy plays a crucial role in islet β-cell maintenance and glucose homeostasis, offering potential targets for therapeutic intervention. Nutrigenomics, which explores how dietary components interact with the genome, has emerged as a promising avenue for disease management. It sheds light on how diet influences gene expression and cellular processes, offering personalized approaches to disease prevention and management. Studies have showed the impact of specific dietary components, such as polyphenols and omega-3 fatty acids, on autophagy processes, suggesting their potential therapeutic benefits in neurodegenerative conditions and metabolic disorders. In cancer, autophagy's dual role in either suppressing tumorigenesis or promoting cancer cell survival underscores the importance of understanding its modulation through dietary interventions. Combined with conventional chemotherapy drugs, dietary compounds show synergistic effects in cancer treatment. Furthermore, phytochemicals such as Indicaxanthin have been found to epigenetically regulate genes involved in autophagy, offering novel insights into personalized cancer therapies.This comprehensive review has the aim to study the autophagy in a combined view with nutrigenomics properties effects of some dietary molecules in maintaining cellular homeostasis and responding to pathological stimuli.Overall, the intersection of autophagy and nutrigenomics effect of bioactive compounds holds promise for developing targeted interventions for various diseases, emphasizing the significance of dietary interventions in disease prevention and management.

    Keywords: Nutrigenomics, Autophagy, Dietary-genetic interactions, Personalized Dietary Approaches, Nutrigenomic Disease Strategies

    Received: 29 Mar 2024; Accepted: 25 Nov 2024.

    Copyright: © 2024 Caradonna, Chiarelli and Naselli. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Roberto Chiarelli, Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Palermo, 90128, Sicily, Italy

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.