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REVIEW article

Front. Nutr.
Sec. Clinical Nutrition
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1408620
This article is part of the Research Topic Comprehensive Nutritional Strategies for Alzheimer's Disease: From Symptom Management to Potential Therapies View all 4 articles

Polyphenol-based polymer nanoparticles for inhibiting amyloid protein aggregation: Recent advances and perspectives

Provisionally accepted
Shuzhen Fang Shuzhen Fang 1Kangyi Zhang Kangyi Zhang 2Danqing Liu Danqing Liu 1Yulong Yang Yulong Yang 1Hu Xi Hu Xi 1Wenting Xie Wenting Xie 1Ke Diao Ke Diao 3Zhihong Rao Zhihong Rao 1Dongxu Wang Dongxu Wang 4Yang Wenming Yang Wenming 1*
  • 1 First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei, Anhui Province, China
  • 2 State Key Laboratory of Tea Plant Biology and Utilization, School of Tea and Food Science and Technology, Anhui Agriculture University, Anhui, Zhejiang Province, China
  • 3 National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China, Beijing, China
  • 4 Jiangsu University of Science and Technology, Zhenjiang, Jiangsu Province, China

The final, formatted version of the article will be published soon.

    Polyphenols are a group of naturally occurring compounds that possess a range of biological properties capable of potentially mitigating or preventing the progression of age-related cognitive decline and Alzheimer's disease (AD). AD is a chronic neurodegenerative disease known as one of the fast-growing diseases, especially in the elderly population. Moreover, as the primary etiology of dementia, it poses challenges for both familial and societal structures, while also imposing a significant economic strain. There is currently no pharmacological intervention that has demonstrated efficacy in treating AD. While polyphenols have exhibited potential in inhibiting the pathological hallmarks of AD, their limited bioavailability poses a significant challenge in their therapeutic application. Furthermore, in order to address the therapeutic constraints, several polymer nanoparticles are being explored as improved therapeutic delivery systems to optimize the pharmacokinetic characteristics of polyphenols. Polymer nanoparticles have demonstrated advantageous characteristics in facilitating the delivery of polyphenols across the blood-brain barrier, resulting in their efficient distribution within the brain. This review focuses on amyloid-related diseases and the role of polyphenols in them, in addition to discussing the anti-amyloid effects and applications of polyphenol-based polymer nanoparticles.

    Keywords: amyloidogenic property, Polyphenols, Nanoparticles, Brain targeting, Nanomedicine

    Received: 03 Apr 2024; Accepted: 17 Jul 2024.

    Copyright: © 2024 Fang, Zhang, Liu, Yang, Xi, Xie, Diao, Rao, Wang and Wenming. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yang Wenming, First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei, Anhui Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.