Skip to main content

ORIGINAL RESEARCH article

Front. Nutr.
Sec. Clinical Nutrition
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1408033
This article is part of the Research Topic Human Milk, Nutrition and Infant Development View all 23 articles

The association of different types of human milk with bronchopulmonary dysplasia in preterm infants

Provisionally accepted
Elisabeth Pütz Elisabeth Pütz 1Rudolf Ascherl Rudolf Ascherl 2Thomas Wendt Thomas Wendt 3Ulrich H. Thome Ulrich H. Thome 2Corinna M. Gebauer Corinna M. Gebauer 2Jon Genuneit Jon Genuneit 1Linda P. Siziba Linda P. Siziba 1*
  • 1 Leipzig University, Leipzig, Lower Saxony, Germany
  • 2 University Hospital Leipzig, Leipzig, Lower Saxony, Germany
  • 3 Data Integration Centre, University Hospital Leipzig, Leipzig, Lower Saxony, Germany

The final, formatted version of the article will be published soon.

    Objective: To evaluate the association between different types of human milk feeds and bronchopulmonary dysplasia (BPD) in preterm infants. Methods: Data on dispensed mother’s own milk (MOM) and donor human milk (DHM) from Leipzig Milk Bank for hospitalized infants with a gestational age (GA) ≤32 weeks observed from birth to 36 weeks’ postmenstrual age or prior discharge were used. BPD was assessed based on documented ICD diagnosis and on electronic hospital records (EHR) of data on ventilation and oxygen supplementation. Associations of dispensed milk feed variations with BPD were investigated using logistic regressions in crude and adjusted models. Results: 866 infants were included with a BPD prevalence of 15.4% (EHR) and 23.2% (ICD). The mean GA was 29.1 weeks. The majority (84.4%, n=746) of infants were nurtured with a mix of MOM, DHM supplemented by formula or parenteral (other) nutrition during hospitalization. For which, MOM comprised the highest median [Q1-Q3] percentage proportion (53[31–81] %) of this mix. Exclusive fresh milk and exclusive MOM feeds were dispensed on a mean of 40% and 34% patient-days, respectively. Statistically significant associations with lower BPD incidence were only observed for 70%-80% MOM vs DHM, and 60% fresh vs frozen milk, in crude and adjusted models. Conclusion: Our findings suggest a protective association of MOM and fresh milk with lower odds of BPD, which may be dependent on the proportion of MOM or fresh milk administered. These results highlight the importance of MOM as an ideal source of nutrition during early infancy.

    Keywords: Bronchopulmonary dysplasia (BPD), donor human milk (DHM), human milk, Leipzig Milk Bank (LMB), Pasteurization, mother's own milk (MOM)

    Received: 27 Mar 2024; Accepted: 15 Jul 2024.

    Copyright: © 2024 Pütz, Ascherl, Wendt, Thome, Gebauer, Genuneit and Siziba. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Linda P. Siziba, Leipzig University, Leipzig, 04109, Lower Saxony, Germany

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.