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ORIGINAL RESEARCH article
Front. Nutr.
Sec. Clinical Nutrition
Volume 11 - 2024 |
doi: 10.3389/fnut.2024.1406733
This article is part of the Research Topic Nutritional Factors in the Development and Prognosis of Inflammatory Bowel Disease (IBD) View all articles
Exploring causal association between malnutrition, nutrients intake and inflammatory bowel disease: A Mendelian randomization analysis
Provisionally accepted- 1 Department of Pediatric Surgery, Tongji Hospital, Wuhan, Hubei Province, China
- 2 Huazhong University of Science and Technology, Wuhan, Hubei Province, China
- 3 Department of Pediatric Surgery, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China
Background: Malnutrition has emerged as main side effects of inflammatory bowel disease (IBD) which might also affect the prognosis of IBD. However, whether these associations are causal remains unclear. We aimed to identify the causality of IBD on malnutrition and explore the causal relationship of malnutrition and nutrients intake on IBD by using Mendelian randomization (MR). Methods: Single nucleotide polymorphisms associated with IBD, malnutrition and nutrients intake were obtained from previous researches of genome-wide association studies (GWAS) (p<0.00000005). MR analysis was conducted to evaluate the causality with different methods based on OR and their 95% CIs. Meanwhile, heterogeneity, pleiotropy and MR-Presso were used for instrumental variables evaluation. Results: The results of MR analysis revealed that IBD, both Crohn disease (CD) and ulcerative colitis (UC), could directly impact the incidence of malnutrition (P value < 0.01). CD is directly related to nutrients such as sugar, fat, VA, VC, VD and zinc, while UC is correlated with carbohydrate, fat, VB12, VC, VD, VE, iron, zinc and magnesium. However, our results suggested that malnutrition could not affect the risk of IBD directly (p>0.05). Further analysis showed similar results that nutrients intake had no direct effect on IBD, neither CD or UC. Conclusions: Our results indicated that IBD increases the risk of malnutrition, however, malnutrition and nutrients intake might not directly affect the progression of IBD.
Keywords: malnutrition1, Nutrients intake2, inflammatory bowel disease3, Mendelian randomization4, GWAS5
Received: 25 Mar 2024; Accepted: 30 Jul 2024.
Copyright: © 2024 Wang, Meng, Yang, Wu, Chen, Li, Xiao, Yu, Chen and Feng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jiexiong Feng, Department of Pediatric Surgery, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China
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