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CLINICAL TRIAL article

Front. Nutr.
Sec. Nutrition, Psychology and Brain Health
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1406366
This article is part of the Research Topic Ketogenic Metabolic Therapy as a Treatment for Mental Health Disorders View all 13 articles

Exploring diet-induced ketosis with exogenous ketone supplementation as a potential intervention in Post-Traumatic Stress Disorder: a feasibility study

Provisionally accepted
Maria G. Edwards Maria G. Edwards 1*Tobias Furuholmen-Jenssen Tobias Furuholmen-Jenssen 1,2*Erik G. Søegaard Erik G. Søegaard 2,3*Suraj B. Thapa Suraj B. Thapa 2,3Jens Rikardt Andersen Jens Rikardt Andersen 1
  • 1 Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark
  • 2 Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Oslo, Norway
  • 3 Division of Mental Health and Addiction, Institute of Clinical Medicine, University of Oslo, Oslo, Norway, Oslo, Norway

The final, formatted version of the article will be published soon.

    Background: Post-Traumatic Stress Disorder (PTSD) is a severe and pervasive mental disorder, and patients experience numerous distressing symptoms and impairments that significantly impact their lives. In addition to being a mental disorder, PTSD is strongly associated with a wide range of metabolic abnormalities that affect the entire body. Existing treatment options of psychotherapy and medications are often ineffective. Exploring other potential treatments is necessitated. The ketogenic diet has shown potential as a metabolic therapy in certain neurological and mental disorders and is a promising intervention in the treatment of PTSD.Aim: This study aimed to examine if a 4-week ketogenic diet intervention supplemented with exogenous ketones was feasible in adult patients with PTSD, to what extent it was possible to recruit patients, attain and maintain ketosis, the occurrence of serious adverse reactions and adverse reactions to KD-KS, and acceptance of treatment. Our exploratory aims were changes in PTSD symptoms and health-related quality of life (QoL) from baseline to 4 weeks.Methods: Patients 18 £ 65 years old, diagnosed with PTSD, and receiving outpatient treatment for

    Keywords: Clinical trial registration: ClinicalTrials.gov, identifier [NCT05415982] Post-Traumatic Stress Disorder (PTSD), Ketogenic diet (KD), Ketosis, Ketogenic Metabolic Therapy (KMT), β-hydroxybutyrate (BHB), exogenous ketones, Ketone Salts (KS)

    Received: 25 Mar 2024; Accepted: 26 Sep 2024.

    Copyright: © 2024 Edwards, Furuholmen-Jenssen, Søegaard, Thapa and Andersen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Maria G. Edwards, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark
    Tobias Furuholmen-Jenssen, Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark
    Erik G. Søegaard, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Oslo, Norway

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.