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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Nutrition and Metabolism
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1406070
This article is part of the Research Topic Calorie Consumption-Related Oxidative Stress in Obesity, Type 2 Diabetes and Cancer Progression View all articles

Heat-killed Bifidobacterium longum BBMN68 and inulin protect against high-fat diet-induced obesity by modulating gut microbiota

Provisionally accepted
Siyuan Sun Siyuan Sun 1Qi Zhang Qi Zhang 1Dongdong Li Dongdong Li 1,2Hongliang Li Hongliang Li 2,3Hairan Ma Hairan Ma 3Xiuying Wu Xiuying Wu 3Yixuan Li Yixuan Li 1Pengjie Wang Pengjie Wang 1Bing Fang Bing Fang 1*Rong Liu Rong Liu 1Haihong Feng Haihong Feng 4Yongxiang Zhang Yongxiang Zhang 5Yue Sang Yue Sang 4Ran Wang Ran Wang 1*
  • 1 Key Laboratory of Functional Dairy, Department of Nutrition and Health, China Agricultural University, Beijing, China
  • 2 Inner Mongolia Mengniu Dairy (Group) Co., Ltd., Hohhot, China
  • 3 Mengniu Hi-Tech Dairy (Beijing) Co., Ltd., Beijing, China
  • 4 Research Center for Probiotics, Department of Nutrition and Health, China Agricultural University, Beijing, China
  • 5 College of Food Science and Engineering, Gansu Agricultural University, Lanzhou, Gansu Province, China

The final, formatted version of the article will be published soon.

    Obesity, a pervasive global epidemic, has heightened susceptibility to chronic ailments and diminished the overall life expectancy on a global scale. Probiotics and inulin (IN) have been documented to mitigate obesity by exerting an influence on the composition of the gut microbiota. Whether heat-killed Bifidobacterium longum BBMN68 (MN68) and IN have an anti-obesity effect remains to be investigated. In this study, Wistar rats were fed a high-fat diet (HFD), and orally administered heat-killed MN68 (2×10 11 CFU/kg) and/or inulin (0.25 kg/kg) for 12 weeks. Heat-killed MN68+IN treatment showed an enhanced effect on preventing weight gain, diminishing fat accumulation, and regulating lipid metabolism, compared to either heat-killed MN68 treatment or inulin treatment. Gut microbiota results showed that heat-killed MN68+IN treatment significantly increased the relative abundance of Bacteroidota, Oscillospira, Intestinimonas, Christensenella, and Candidatus_Stoquefichus, and reduced the relative abundance of Enterococcus. Furthermore, heatkilled MN68+IN significantly increased the SCFA levels, which were correlated with changes in the gut microbiota. This research may provide support for the application of heat-killed MN68 and IN in the treatment of obesity.

    Keywords: Bifidobacterium longum BBMN68, Inulin, Obesity, Gut Microbiota, Heat-killed

    Received: 24 Mar 2024; Accepted: 30 Jul 2024.

    Copyright: © 2024 Sun, Zhang, Li, Li, Ma, Wu, Li, Wang, Fang, Liu, Feng, Zhang, Sang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Bing Fang, Key Laboratory of Functional Dairy, Department of Nutrition and Health, China Agricultural University, Beijing, China
    Ran Wang, Key Laboratory of Functional Dairy, Department of Nutrition and Health, China Agricultural University, Beijing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.