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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Nutrigenomics
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1405663

The Association Between Dietary Consumption Habits and Psoriasis: A Two-Sample Mendelian Randomization Study

Provisionally accepted
Minghui Lu Minghui Lu 1,2Changyong Gao Changyong Gao 2Runtian Zhang Runtian Zhang 2*Jianhong Li Jianhong Li 2*Xi Chen Xi Chen 2*Lingling Yuan Lingling Yuan 2*
  • 1 Beijing University of Chinese Medicine, Beijing, China
  • 2 Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, Beijing Municipality, China

The final, formatted version of the article will be published soon.

    Background: Psoriasis is a chronic inflammatory skin disease characterized primarily by erythema and scales, having a wide-ranging impact globally. Previous studies have suggested that dietary consumption habits may influence psoriasis. The objective of this study was to determine the causal relationship between dietary consumption habits and psoriasis using the Mendelian Randomization (MR) approach. Methods: SNP data for 29 dietary consumption habits and psoriasis were obtained from the GWAS catalog database and the FinnGen database, respectively. The Mendelian Randomization analysis was performed using R software, with the 29 dietary consumption habits as the exposure factors and psoriasis as the outcome. Three MR analysis methods-Inverse Variance Weighted (IVW), Weighted Median Estimator (WME), and MR-Egger regression-were employed to study the causal relationship between dietary consumption habits and psoriasis. Results: The IVW analysis indicated an OR (95%CI) of 0.065 (0.008-0.555), P = 0.012, demonstrating a negative correlation between the consumption of dried fruit and psoriasis. Conclusion: Among the 29 dietary consumption habits analyzed, the intake of dried fruits is a protective factor against psoriasis. Therefore, it is clinically advisable to appropriately increase the intake of dried fruits among patients with psoriasis, serving as a nutritional therapy method in conjunction with pharmacological treatment.

    Keywords: Psoriasis, Dietary Consumption Habits, Mendelian randomization, Dry fruit, GWAS

    Received: 23 Mar 2024; Accepted: 07 Oct 2024.

    Copyright: © 2024 Lu, Gao, Zhang, Li, Chen and Yuan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Runtian Zhang, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100001, Beijing Municipality, China
    Jianhong Li, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100001, Beijing Municipality, China
    Xi Chen, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100001, Beijing Municipality, China
    Lingling Yuan, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100001, Beijing Municipality, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.