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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Nutrition and Microbes
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1395801

Association of Gut Microbiota with Lactose Intolerance and Coeliac Disease: A Two-Sample Mendelian Randomization Study

Provisionally accepted
Zongze Han Zongze Han YING RAN YING RAN Jiwen Li Jiwen Li Xue Zhang Xue Zhang Hui Yang Hui Yang Jiangpeng Liu Jiangpeng Liu Shijing Dong Shijing Dong Hao Jia Hao Jia Zhen Yang Zhen Yang Yanni Li Yanni Li Liping Guo Liping Guo Simin Zhou Simin Zhou Suriguge Bao Suriguge Bao Wei Yuan Wei Yuan Bangmao Wang Bangmao Wang Lu Zhou Lu Zhou *
  • Tianjin Medical University General Hospital, Tianjin, China

The final, formatted version of the article will be published soon.

    Background and objectives: Lactose intolerance and coeliac disease are common clinical nutrient malabsorption disorders, with an unclear pathogenesis and limited therapeutic options. It is widely believed that the gut microbiota plays an important role in many digestive disorders, but its role in lactose intolerance and coeliac disease is not yet clear. This study aimed to investigate the correlation between gut microbiota and lactose intolerance and coeliac disease. Materials and methods: This study utilized the genome-wide association study database to investigate the association between gut microbiota and lactose intolerance and coeliac disease using Mendelian randomization (MR). The robustness of our findings was confirmed through subsequent analyses including Cochrane's Q statistic, MR-Egger Intercept Regression, MR-PRESSO Global Test and Leave-one-out methods. Results: By employing the inverse variance weighted method, we identified that family Veillonellaceae, genus Oxalobacter and Senegalimassilia were protective against lactose intolerance, whereas genus Anaerotruncus, Eubacterium rectale group and Ruminococcus2 were found to be risk factors for lactose intolerance. Regarding coeliac disease, class Bacilli and Gammaproteobacteria, family FamilyXIII and Veillonellaceae, genus Eisenbergiella, Lachnoclostridium, RuminococcaceaeUCG014 and Ruminococcus2 were identified as protective factors, while class Betaproteobacteria, genus Eubacterium xylanophilum group and Blautia were risk factors. Furthermore, reverse the MR analysis did not reveal any evidence of a causal relationship between lactose intolerance or coeliac disease and the bacteria identified in our study. Conclusion: This study provides novel insights into exploring the role of gut microbiota in lactose intolerance and coeliac disease; however, further experiments investigations are required to elucidate the specific underlying mechanisms.

    Keywords: Lactose Intolerance, coeliac disease, Gut Microbiota, Mendelian randomization, Genome-Wide Association Study

    Received: 04 Mar 2024; Accepted: 23 Jul 2024.

    Copyright: © 2024 Han, RAN, Li, Zhang, Yang, Liu, Dong, Jia, Yang, Li, Guo, Zhou, Bao, Yuan, Wang and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Lu Zhou, Tianjin Medical University General Hospital, Tianjin, 300052, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.