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REVIEW article
Front. Nutr.
Sec. Nutrition and Microbes
Volume 11 - 2024 |
doi: 10.3389/fnut.2024.1393575
The Anti-obesity Effects of Polyphenols: A Comprehensive Review of Molecular Mechanisms and Signal Pathways in Regulating Adipocytes
Provisionally accepted- 1 First People's Hospital of Wenling, Wenling, China
- 2 Hunan Agricultural University, Changsha, Hunan, China
Excess weight gain is a growing concern worldwide, fueled by increased consumption of calorie-dense foods and more sedentary lifestyles. Obesity in China is also becoming increasingly problematic, developing into a major public health concern. Obesity not only increases the risk of associated disease but also imposes a burden on health care systems, and it is thus imperative that an effective intervention approach be identified. Recent studies have demonstrated that the polyphenol-rich Mediterranean diet has considerable potential in this regard. Polyphenols can inhibit the production of adipocytes and reduce adverse reactions, such as inflammation, insulin resistance, and gut microflora imbalance. In this review, we examine four polyphenols (curcumin, ellagic acid, ferulic acid and quercetin) in terms of their potential as interventions targeting obesity.The mechanisms that help promote adipocyte browning, increase thermogenic factors, increase thermogenesis, and regulate adipocyte differentiation are summarized, and key signaling pathways, including PPARγ, C/EBP-, and others, are reviewed.
Keywords: polyphenol, Obesity, Adipose Tissue, antioxidant effect, Gut Microbiota, Inflammatory reaction, Signal pathways LPS: Lipopolysaccharides CD14: cluster of differentiation 14 BAs: bile acids HFD: high-fat diet GM: Gut Microbes Acetyl-CoA carboxylase 2 STAT3: transcriptional activator 3 Forkhead box O1 GLUT4: Glucose Transporter 4
Received: 01 Mar 2024; Accepted: 10 Oct 2024.
Copyright: © 2024 He, Su and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Shuangshuang Wang, First People's Hospital of Wenling, Wenling, 317500, China
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