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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Clinical Nutrition
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1391983
This article is part of the Research Topic Women's Health in an Interdisciplinary Dimension – Determinants of Nutritional Disorders View all 15 articles

Dietary Inflammatory Index and Female Infertility: Findings from NHANES Survey

Provisionally accepted
Wenhui Wang Wenhui Wang Yuxiao Dong Yuxiao Dong Kun Wang Kun Wang Heming Sun Heming Sun Huan Yu Huan Yu *Bin Ling Bin Ling *
  • China-Japan Friendship Hospital, Beijing, China

The final, formatted version of the article will be published soon.

    Background and Objectives: Infertility is a pressing public health concern on a national scale and has been linked to inflammatory conditions. However, limited research has been conducted on the impact of the dietary inflammatory index (DII) on female infertility. This study sought to investigate the association between DII and infertility utilizing data from the National Health and Nutrition Examination Survey (NHANES).This cross-sectional study included a cohort of 3,071 women aged 20-44 years from three NHANES cycles (2013)(2014)(2015)(2016)(2017)(2018). Dietary information was collected to calculate the Dietary Inflammatory Index (DII), while infertility status was determined through positive responses to specific questions in a questionnaire. The association between DII scores and infertility was assessed using adjusted multivariate logistic regression analyses. Subgroup analysis and restricted cubic spline (RCS) was conducted for further investigation.Results: Among the participants, 354 women (11.53%) were identified as experiencing infertility. Upon adjusting for all covariates, a positive correlation was observed (OR = 1.61, 95% CI 1.12-2.31). Individuals with DII scores in the highest quartile exhibited significantly greater odds of infertility compared to those in the lowest quartile (OR = 1.71, 95% CI = 1.17-2.51). The relationship between DII and infertility in the RCS models demonstrated an S-shaped curve. When using the median DII as a reference point, a higher DII was associated with an increased prevalence of infertility. Additionally, obesity was found to be a significant factor.Conclusions: Our research indicated that the DII was positively correlated with an increased likelihood of infertility in American women among the ages of 20 and 44. These results contribute to the existing literature and underscore the need for further validation through larger prospective cohort studies.

    Keywords: Infertility, Dietary inflammatory index, Diet, Inflammation, NHANES

    Received: 26 Feb 2024; Accepted: 28 Aug 2024.

    Copyright: © 2024 Wang, Dong, Wang, Sun, Yu and Ling. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Huan Yu, China-Japan Friendship Hospital, Beijing, China
    Bin Ling, China-Japan Friendship Hospital, Beijing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.