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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Clinical Nutrition
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1390668

The Vitamin D Status in a Chinese Osteogenesis Imperfecta Population and Its Correlation with Bone Metabolic Markers and Bone Density

Provisionally accepted
Yunyi Jiang Yunyi Jiang 1Yazhao Mei Yazhao Mei 1Yuan Tian Yuan Tian 1Li Shen Li Shen 2Shuqin Xu Shuqin Xu 1Hao Zhang Hao Zhang 1*ZhenLin Zhang ZhenLin Zhang 1*
  • 1 Department of Osteoporosis and Bone Diseases, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, China
  • 2 Clinical Research Center, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, Shanghai Municipality, China

The final, formatted version of the article will be published soon.

    Objective: Studies on the baseline vitamin D levels in osteogenesis imperfecta (OI) patients before medication are scarce. This study assessed the vitamin D status of a population with OI at both the overall level and within different age groups. It correlated baseline 25-hydroxyvitamin D (25(OH)D) levels with other bone-related factors, biochemical markers, and bone density.We collected 25-hydroxyvitamin D (25(OH)D) levels from 95 OI patients in East China (59 under 18 years old and 36 over 18 years old). Patients who were postmenopausal, males over 50 years old). Measurements included body indicators, biochemical markers, and bone mineral density (BMD) assessed by Dual-energy X-ray absorptiometry (DXA). Data analysis was performed using SPSS 26.0.In the overall population, among those under 18 years old, and among those over 18 years old, 87.4%, 83.1%, and 94.4% respectively were vitamin D deficient (<30 ng/mL), while 47.4%, 40.7%, and 58.3% had vitamin D deficiency (<20 ng/mL), respectively. In the overall population and among those under 18 years old, serum 25(OH)D levels were negatively correlated with age and parathyroid hormone (PTH) levels, and 25(OH)D levels (<10 ng/mL, 10-20 ng/mL, 20-30 ng/mL, >30 ng/mL) showed a negative correlation with BMI. In OI patients under 18 years old, serum 25(OH)D was negatively correlated with serum β-CTX levels. In adult male OI population, 25(OH)D levels were negatively correlated with OI severity (Type I, IV, III). No statistically significant correlation was found between 25(OH)D levels and bone density Z scores.This study on OI in East China reveals significant vitamin D insufficiency and deficiency in baseline levels among pediatric, adolescent and adult OI patients. It assesses the correlation of 25(OH)D levels with various influencing factors, providing crucial insights into understanding the impact of OI on vitamin D status across different age groups and aiding in better clinical management of OI patients.

    Keywords: Osteogenesis Imperfecta, Vitamin D, bone mineral density, Bone metabolic markers, China

    Received: 23 Feb 2024; Accepted: 12 Jul 2024.

    Copyright: © 2024 Jiang, Mei, Tian, Shen, Xu, Zhang and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Hao Zhang, Department of Osteoporosis and Bone Diseases, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, 200233, China
    ZhenLin Zhang, Department of Osteoporosis and Bone Diseases, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, 200233, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.