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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Sport and Exercise Nutrition
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1386389
This article is part of the Research Topic Food and Nutrition for Athletics: Redefining the Role and Application View all articles

Effect of kaempferol ingestion on physical activity and sleep quality: a double-blind, placebo-controlled, randomized, crossover trial

Provisionally accepted
Yasutaka Ikeda Yasutaka Ikeda 1*Aina Gotoh-Katoh Aina Gotoh-Katoh 1Shinpei Okada Shinpei Okada 2Shuichi Handa Shuichi Handa 2Teruyuki Sato Teruyuki Sato 2Tsubasa Mizokami Tsubasa Mizokami 1Bungo Saito Bungo Saito 2,3
  • 1 Otsuka Pharmaceutical Co. Ltd, Tokyo, Japan
  • 2 Physical Education and Medicine Research Foundation, Tomi, Japan
  • 3 Mimaki Onsen Clinic, Tomi, Japan

The final, formatted version of the article will be published soon.

    Background: Kaempferol (KMP), a flavonoid in edible plants, exhibits diverse pharmacological effects. Growing body of evidence associates extended lifespan with physical activity (PA) and sleep, but KMP's impact on these behaviors is unclear. This double-blind, placebo-controlled, crossover trial assessed KMP's effects on PA and sleep. Methods: A total of 33 city workers (17 males and 16 females) participated in this study. They were randomly assigned to take either 10 mg of KMP or placebo for two weeks in the order allocated, with a 7-day washout period in between. All participants wore an accelerometer-based wearable device (Fitbit Charge 4), which monitored daily PA, heart rate (HR), and HR variability during sleep. Results: The duration of wearing the device was 23.73±0.04 h/day. HR decreased in each PA level, and the mean daily step count and distance covered increased significantly during KMP intake compared to placebo. The outing rate, number of trips, number of recreational activities, and time spent in recreation on weekends increased. Sleep quality improved following KMP intake. The decrease in HR and increase in RMSSD may be important in mediating the effects of these KMPs. Conclusions: KMP leads to behavioral changes that subsequently improve sleep quality and potentially improve long-term quality of life. Trial registration: UMIN Clinical Trials Registry (https://center6.umin.ac.jp/cgi-openbin/ctr_e/ctr_view.cgi?recptno=R000048447; No. UMIN000042438; Date: 13 Nov 2020).

    Keywords: Behavioral changes, Daily step count, sleep quality, Fitbit, Kaempferols

    Received: 14 Mar 2024; Accepted: 25 Jul 2024.

    Copyright: © 2024 Ikeda, Gotoh-Katoh, Okada, Handa, Sato, Mizokami and Saito. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yasutaka Ikeda, Otsuka Pharmaceutical Co. Ltd, Tokyo, Japan

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.