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ORIGINAL RESEARCH article

Front. Nutr.
Sec. Nutritional Epidemiology
Volume 11 - 2024 | doi: 10.3389/fnut.2024.1359644
This article is part of the Research Topic Anemia − Tackling a Complex Problem View all 9 articles

Deficient Constitution-Related Increases the Tendency for Anemia Is Associated with Gut Microbiome

Provisionally accepted
Yuanjun Liang Yuanjun Liang 1,2*Yang Chen Yang Chen 1,2Yanzhao Lin Yanzhao Lin 1,2*Wei Huang Wei Huang 1,2*Qinwei Qiu Qinwei Qiu 1,2Chen Sun Chen Sun 1,2*Jiamin Yuan Jiamin Yuan 1,2*Ning Xu Ning Xu 1Xinyan Chen Xinyan Chen 1,2*Fuping XU Fuping XU 1,2Xiaoxiao Shang Xiaoxiao Shang 1,2Yusheng Deng Yusheng Deng 1,2*Yanmin Liu Yanmin Liu 1,2Fei Tan Fei Tan 1,2*Chunxiang He Chunxiang He 1,2*Jiasheng Li Jiasheng Li 1*Qinqin Deng Qinqin Deng 1*Xiaoxuan Zhang Xiaoxuan Zhang 1,2*Huahua Guan Huahua Guan 1,2*Yongzhu Liang Yongzhu Liang 1*Lijuan Han Lijuan Han 3*Xuanting Jiang Xuanting Jiang 3Xiaodong Fang Xiaodong Fang 1,2*Xiaodong Fang Xiaodong Fang 1,2*Zhimin Yang Zhimin Yang 1,2*
  • 1 Guangdong Provincial Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China
  • 2 State Key Laboratory of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China
  • 3 Department of Scientific Research, Kangmeihuada GeneTech Co., Ltd.,, Shenzhen, China

The final, formatted version of the article will be published soon.

    Background: Constitution is a valuable part of traditional Chinese medicine theory; it is defined as the internal foundation for the occurrence, development, transformation and outcome of diseases, and has its characteristic gut microbiota.Previous study showed that deficiency constitution was related to lower Hb counts.However, no research has examined how alterations in the gut microbiome induced by deficiency constitution may increase the tendency for anemia. Methods: We used a multiomics strategy to identify and quantify taxonomies and compounds found under deficient constitution individuals and further explore the possible pathological factors that affect red blood cell indices. Results: ① People with deficient constitution showed lower hemoglobin(Hb), more Firmicutes, less Bacteroidetes, and higher α diversity. ② We identified Escherichia coli, Clostridium bolteae, Ruminococcus gnavus, Streptococcus parasanguinis and Flavonifractor plautii as potential biomarkers of deficient constitution. ③ Slackia piriformis, Clostridium_sp_L2_50 and Bacteroides plebeius were enriched in balanced-constitution individuals, and Parabacteroides goldsteinii was the key bacterial marker of balanced constitution. ④ Flavonifractor plautii may be a protective factor against the tendency for anemia among deficient individuals. ⑤ Ruminococcus gnavus may be the shared microbe base of deficiency constitution-related the tendency for anemia. ⑥ The microorganism abundance of the anaerobic phenotype was lower in deficient constitution group. ⑦ Alterations in the microbiome of deficient-constitution individuals were associated with worse health status and a greater risk of anemia, involving intestinal barrier function, metabolism and immune responses, regulated by short-chain fatty acids and bile acid production. Conclusion: The composition of the gut microbiome was altered in people with deficient constitution, which may explain their poor health status and tendency towards anemia.

    Keywords: Traditional Chinese medicine constitution, Deficient constitution, Anemia, gut microbiome, serum metabolomics

    Received: 20 Mar 2024; Accepted: 23 Jul 2024.

    Copyright: © 2024 Liang, Chen, Lin, Huang, Qiu, Sun, Yuan, Xu, Chen, XU, Shang, Deng, Liu, Tan, He, Li, Deng, Zhang, Guan, Liang, Han, Jiang, Fang, Fang and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yuanjun Liang, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China
    Yanzhao Lin, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China
    Wei Huang, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China
    Chen Sun, State Key Laboratory of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China
    Jiamin Yuan, State Key Laboratory of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China
    Xinyan Chen, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China
    Yusheng Deng, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China
    Fei Tan, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China
    Chunxiang He, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China
    Jiasheng Li, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China
    Qinqin Deng, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China
    Xiaoxuan Zhang, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China
    Huahua Guan, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China
    Yongzhu Liang, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China
    Lijuan Han, Department of Scientific Research, Kangmeihuada GeneTech Co., Ltd.,, Shenzhen, China
    Xiaodong Fang, State Key Laboratory of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China
    Xiaodong Fang, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China
    Zhimin Yang, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China

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