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REVIEW article
Front. Neurosci.
Sec. Neurodevelopment
Volume 18 - 2024 |
doi: 10.3389/fnins.2024.1451740
Interplay of epilepsy and long-term potentiation: Implications for memory
Provisionally accepted
Luis A. Marin-Castañeda
1
Geronimo Pacheco Aispuro
2
Guillermo Gonzalez-Garibay
1,3
Carlos Alejandro Martínez Zamora
1,3
Héctor Romo-Parra
1,3
Carmen Rubio
1,3*
Moisés Rubio-Osornio
4*- 1 Departamento de Neuroinmunología, Manuel Velasco Suárez Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico
- 2 Hospital Angeles Pedregal, Mexico City, México, Mexico
- 3 Departamento de Neuroinmunología, Manuel Velasco Suárez Instituto Nacional de Neurología y Neurocirugía, Mexico City, México, Mexico
- 4 Departamento de Neuroquímica, Manuel Velasco Suárez Instituto Nacional de Neurología y Neurocirugía., Mexico City, México, Mexico
The interplay between Long-term potentiation (LTP) and epilepsy represents a crucial facet in understanding synaptic plasticity and memory within neuroscience. LTP, a phenomenon characterized by a sustained increase in synaptic strength, is pivotal in learning and memory processes, particularly in the hippocampus. This review delves into the intricate relationship between LTP and epilepsy, exploring how alterations in synaptic plasticity mechanisms akin to those seen in LTP contribute to the hyperexcitable state of epilepsy. This state is conceptualized as a dysregulation between LTP and LTD (Long-term depression), leading to pathologically enhanced synaptic efficacy.Additionally, the role of neuroinflammation in both LTP and epilepsy is examined, highlighting how inflammatory mediators can influence synaptic plasticity. The dual role of neuroinflammatory pathways, enhancing or inhibiting LTP, is a focal area of ongoing research. The significance of various signaling pathways, including the MAPK, mTOR, and WNT/β-catenin pathways, in the modulation of synaptic plasticity and their relevance in both LTP and epilepsy. These pathways are instrumental in memory formation, consolidation, and epileptogenesis, illustrating a complex interaction between cellular mechanisms in the nervous system.Lastly, the role of calcium signaling in the relationship between LTP and epilepsy is scrutinized.Aberrant calcium signaling in epilepsy leads to an enhanced, yet pathologically altered, LTP. This dysregulation disrupts normal neural pathways, potentially leading to cognitive dysfunction, particularly in memory encoding and retrieval. The review emphasizes the need for targeted interventions in epilepsy that address cognitive functions alongside seizure control.
Keywords: Long-Term Potentiation, Epilepsy, synaptic plasticity, Neuroinflammation, Memory
Received: 17 Sep 2024; Accepted: 20 Dec 2024.
Copyright: © 2024 Marin-Castañeda, Pacheco Aispuro, Gonzalez-Garibay, Martínez Zamora, Romo-Parra, Rubio and Rubio-Osornio. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Carmen Rubio, Departamento de Neuroinmunología, Manuel Velasco Suárez Instituto Nacional de Neurología y Neurocirugía, Mexico City, México, Mexico
Moisés Rubio-Osornio, Departamento de Neuroquímica, Manuel Velasco Suárez Instituto Nacional de Neurología y Neurocirugía., Mexico City, México, Mexico
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