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ORIGINAL RESEARCH article

Front. Neurol.
Sec. Neuro-Otology
Volume 15 - 2024 | doi: 10.3389/fneur.2024.1484488
This article is part of the Research Topic Challenges and Current Research Status of Vertigo/Vestibular Diseases Volume III View all 6 articles

Commissural and monosynaptic inputs to medial vestibular nucleus GABAergic neurons in mice

Provisionally accepted
Dedi Kong Dedi Kong Lingxi Kong Lingxi Kong Chengwei Liu Chengwei Liu Qianru Wu Qianru Wu Jing Wang Jing Wang Chunfu DAI Chunfu DAI *
  • Department of Otology and Skull Base Surgery, Eye Ear Nose and Throat Hospital, Fudan University,, Shanghai, China

The final, formatted version of the article will be published soon.

    Objective: MVN GABAergic neurons is involved in the rebalance of commissural system contributing to alleviating acute peripheral vestibular dysfunction syndrome. This study aims to depict monosynaptic inputs to MVN GABAergic neurons. Methods: The modified rabies virusbased retrogradation method combined with the Vgat-cre mice was used in this study. Moreover, the commissural connections with MVN GABAergic neurons were analyzed. Results: We identified sixty nuclei projecting to MVN GABAergic neurons primarily distributed in the cerebellum and the medulla. The uvula-nodulus, gigantocellular reticular nucleus, prepositus nucleus, intermediate reticular nucleus, and three other nuclei sent dense inputs to MVN GABAergic neurons. The medial (fastigial) cerebellar nucleus, dorsal paragigantocellular nucleus, lateral paragigantocellular nucleus and 10 other nuclei sent moderate inputs to MVN GABAergic neurons. Sparse inputs to MVN GABAergic neurons originated from the nucleus of the solitary tract, lateral reticular nucleus, pedunculopontine tegmental nucleus and 37 other nuclei. The MVN GABAergic neurons were regulated by the contralateral MVN, lateral vestibular nucleus, superior vestibular nucleus, and inferior vestibular nucleus. Conclusions: Our study contributes to further understanding of the vestibular dysfunction in terms of neural circuits and search for new strategies to facilitate vestibular compensation.

    Keywords: Number of figures, Tables: 7, 0 vestibular function, vestibular disorders, medial vestibular nucleus, GABAergic Neurons

    Received: 21 Aug 2024; Accepted: 18 Sep 2024.

    Copyright: © 2024 Kong, Kong, Liu, Wu, Wang and DAI. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Chunfu DAI, Department of Otology and Skull Base Surgery, Eye Ear Nose and Throat Hospital, Fudan University,, Shanghai, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.