Frontiers in Molecular Neuroscience | Brain Disease Mechanisms

Original Research

Published on 20 Feb 2025

Multi-omics-based phenotyping of AFG3L2-mutant lymphoblasts determines key factors of a pathophysiological interplay between mitochondrial vulnerability and neurodegeneration in spastic ataxia type 5

in Brain Disease Mechanisms

Menekse Oeztuerk
Diran Herebian
Kale Dipali
Andreas Hentschel
Nina Rademacher
Florian Kraft
Rita Horvath
Felix Distelmaier
Sven G. Meuth
Tobias Ruck

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1548255

Original Research

Published on 19 Feb 2025

Impaired cerebrospinal fluid circulation and cerebral lymphatic drainage in a rat model of chronic hydrocephalus

in Brain Disease Mechanisms

Dong Bin Back
Bo-Ryoung Choi
Kyoung Ja Kwon
Dong-Hee Choi
Chan Young Shin
Jongmin Lee
Hahn Young Kim

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1516265

Opinion

Published on 18 Feb 2025

Histone monoaminylation is a novel epigenetic mechanism in psychiatric disorders

in Brain Disease Mechanisms

Jacob Peedicayil
Samuel Santhosh

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1534569

291 views

Original Research

Published on 13 Feb 2025

Deciphering motor dysfunction and microglial activation in mThy1-α-synuclein mice: a comprehensive study of behavioral, gene expression, and methylation changes

in Brain Disease Mechanisms

Brett A. McGregor
Md. Obayed Raihan
Afrina Brishti
Junguk Hur
James E. Porter

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1544971

203 views

Review

Published on 11 Feb 2025

The emerging role of glycine receptor α2 subunit defects in neurodevelopmental disorders

in Brain Disease Mechanisms

Sean D. Fraser
Robert J. Harvey

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1550863

303 views

Original Research

Accepted on 05 Feb 2025

Hippocampal RNA-Seq in a F2 Cross of bHR/bLR rats 1 Bioenergetic-Related Gene Expression in the Hippocampus Predicts Internalizing vs. Externalizing Behavior in an Animal Model of Temperament

in Brain Disease Mechanisms

Elaine K Hebda-Bauer
Megan Hastings Hagenauer
Daniel Munro
Peter Blandino
Fan Meng
Keiko Arakawa
Apurva S Chitre
Ayse Bilge Ozel
Pejman Mohammadi
Stanley J Watson

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1469467

Original Research

Published on 05 Feb 2025

The effect of AKT inhibition in α-synuclein-dependent neurodegeneration

in Brain Disease Mechanisms

Bedri Ranxhi
Zoya R. Bangash
Zachary M. Chbihi
Sokol V. Todi
Peter A. LeWitt
Wei-Ling Tsou

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1524044

333 views

Original Research

Published on 05 Feb 2025

Ectopic expression of the cation-chloride cotransporter KCC2 in blood exosomes as a biomarker for functional rehabilitation

in Brain Disease Mechanisms

L. Caccialupi Da Prato
A. Rezzag Lebza
A. Consumi
M. Tessier
A. Srinivasan
C. Rivera
J. Laurin
C. Pellegrino

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1522571

251 views

Original Research

Published on 29 Jan 2025

Short- and long-term changes in neurological, behavioural, and blood biomarkers following repeated mild traumatic brain injury in rats—potential biological sex-dependent effects

in Brain Disease Mechanisms

Rodrigo Moraga-Amaro
Oscar Moreno
Jordi Llop
Marion Bankstahl
Jens P. Bankstahl

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1488261

644 views

Review

Published on 27 Jan 2025

Regulatory mechanism of Reelin activity: a platform for exploiting Reelin as a therapeutic agent

in Brain Disease Mechanisms

Mitsuharu Hattori

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1546083

493 views

Original Research

Published on 15 Jan 2025

Uncovering novel KCC2 regulatory motifs through a comprehensive transposon-based mutant library

in Brain Disease Mechanisms

Pavel Uvarov
Satoshi Fudo
Cem Karakus
Andrey Golubtsov
Federico Rotondo
Tatiana Sukhanova
Shetal Soni
Coralie Di Scala
Tommi Kajander
Claudio Rivera

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1505722

1,072 views

Review

Published on 14 Jan 2025

Novel strategies targeting mitochondria-lysosome contact sites for the treatment of neurological diseases

in Brain Disease Mechanisms

Yinyin Xie
Wenlin Sun
Aoya Han
Xinru Zhou
Shijie Zhang
Changchang Shen
Yi Xie
Cui Wang
Nanchang Xie

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1527013

764 views

Editorial

Published on 13 Jan 2025

Editorial: Oxytosis/ferroptosis: unraveling the mechanisms and its multifaceted role in neurodegenerative diseases

in Brain Disease Mechanisms

Nawab John Dar
David Soriano Castell
Shahnawaz Ali Bhat
Pamela Maher

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1547301

653 views

Original Research

Published on 10 Jan 2025

Serum metabolomic signatures of patients with rare neurogenetic diseases: an insight into potential biomarkers and treatment targets

in Brain Disease Mechanisms

Nalaka Wijekoon
Lakmal Gonawala
Pyara Ratnayake
Darshana Sirisena
Harsha Gunasekara
Athula Dissanayake
Dhammika Amaratunga
Harry W. M. Steinbusch
Yetrib Hathout
Eric P. Hoffman

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1482999

624 views

Original Research

Published on 10 Jan 2025

Neurotherapeutic impact of vanillic acid and ibudilast on the cuprizone model of multiple sclerosis

in Brain Disease Mechanisms

Rasha M. Alderbi
Mohammad Z. Alam
Badrah S. Alghamdi
Hadeil M. Alsufiani
Gamal S. Abd El-Aziz
Ulfat M. Omar
Maryam A. Al-Ghamdi

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1503396

634 views

Review

Published on 07 Jan 2025

Genetic and molecular mechanisms of hydrocephalus

in Brain Disease Mechanisms

Xuehai Deng
Yiqian Chen
Qiyue Duan
Jianlin Ding
Zhong Wang
Junchi Wang
Xinlong Chen
Liangxue Zhou
Long Zhao

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1512455

629 views

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Articles

Multi-omics-based phenotyping of AFG3L2-mutant lymphoblasts determines key factors of a pathophysiological interplay between mitochondrial vulnerability and neurodegeneration in spastic ataxia type 5

Impaired cerebrospinal fluid circulation and cerebral lymphatic drainage in a rat model of chronic hydrocephalus

Histone monoaminylation is a novel epigenetic mechanism in psychiatric disorders

Deciphering motor dysfunction and microglial activation in mThy1-α-synuclein mice: a comprehensive study of behavioral, gene expression, and methylation changes

The emerging role of glycine receptor α2 subunit defects in neurodevelopmental disorders

Hippocampal RNA-Seq in a F2 Cross of bHR/bLR rats 1 Bioenergetic-Related Gene Expression in the Hippocampus Predicts Internalizing vs. Externalizing Behavior in an Animal Model of Temperament

The effect of AKT inhibition in α-synuclein-dependent neurodegeneration

Ectopic expression of the cation-chloride cotransporter KCC2 in blood exosomes as a biomarker for functional rehabilitation

Short- and long-term changes in neurological, behavioural, and blood biomarkers following repeated mild traumatic brain injury in rats—potential biological sex-dependent effects

Regulatory mechanism of Reelin activity: a platform for exploiting Reelin as a therapeutic agent

Uncovering novel KCC2 regulatory motifs through a comprehensive transposon-based mutant library

Novel strategies targeting mitochondria-lysosome contact sites for the treatment of neurological diseases

Editorial: Oxytosis/ferroptosis: unraveling the mechanisms and its multifaceted role in neurodegenerative diseases

Serum metabolomic signatures of patients with rare neurogenetic diseases: an insight into potential biomarkers and treatment targets

Neurotherapeutic impact of vanillic acid and ibudilast on the cuprizone model of multiple sclerosis

Genetic and molecular mechanisms of hydrocephalus