Original Research

Published on 10 Jan 2025

Serum metabolomic signatures of patients with rare neurogenetic diseases: an insight into potential biomarkers and treatment targets

in Brain Disease Mechanisms

Nalaka Wijekoon
Lakmal Gonawala
Pyara Ratnayake
Darshana Sirisena
Harsha Gunasekara
Athula Dissanayake
Dhammika Amaratunga
Harry W. M. Steinbusch
Yetrib Hathout
Eric P. Hoffman

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1482999

230 views

Original Research

Published on 10 Jan 2025

Neurotherapeutic impact of vanillic acid and ibudilast on the cuprizone model of multiple sclerosis

in Brain Disease Mechanisms

Rasha M. Alderbi
Mohammad Z. Alam
Badrah S. Alghamdi
Hadeil M. Alsufiani
Gamal S. Abd El-Aziz
Ulfat M. Omar
Maryam A. Al-Ghamdi

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1503396

222 views

Original Research

Accepted on 08 Jan 2025

The effect of AKT inhibition in α-synuclein-dependent neurodegeneration

in Brain Disease Mechanisms

Bedri Ranxhi
Zoya R Bangash
Zachary M Chbihi
Sokol V Todi
Peter A Lewitt
Wei-Ling Tsou

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1524044

Review

Published on 07 Jan 2025

Genetic and molecular mechanisms of hydrocephalus

in Brain Disease Mechanisms

Xuehai Deng
Yiqian Chen
Qiyue Duan
Jianlin Ding
Zhong Wang
Junchi Wang
Xinlong Chen
Liangxue Zhou
Long Zhao

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1512455

167 views

Review

Accepted on 30 Dec 2024

Novel Strategies Targeting Mitochondria-Lysosome Contact Sites for the Treatment of Neurological Diseases

in Brain Disease Mechanisms

Yinyin Xie
Sun Wenlin
Aoya Han
Xinru Zhou
Shijie Zhang
Changchang Shen
Yi Xie
Cui Wang
Nanchang Xie

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1527013

Review

Published on 24 Dec 2024

The role of Aha1 in cancer and neurodegeneration

in Brain Disease Mechanisms

Brian S.J. Blagg
Kevin C. Catalfano

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1509280

506 views

Editorial

Accepted on 23 Dec 2024

Oxytosis/Ferroptosis: Unraveling the mechanisms and its multifaceted role in neurodegenerative diseases

in Brain Disease Mechanisms

Nawab John Dar
David Soriano Castell
David Soriano Castell
Pamela Maher

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1547301

101 views

Original Research

Published on 20 Dec 2024

Analysis of the pathogenicity and pathological characteristics of NOTCH3 gene-sparing cysteine mutations in vitro and in vivo models

in Brain Disease Mechanisms

Zhenping Gong
Wan Wang
Ying Zhao
Yadan Wang
Ruihua Sun
Haohan Zhang
Fengyu Wang
Yaru Lu
Jiewen Zhang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1391040

368 views

Original Research

Published on 18 Dec 2024

Circulating miR-134 in mesial temporal lobe epilepsy: implications in hippocampal sclerosis development and drug resistance

in Brain Disease Mechanisms

Bárbara Guerra Leal
Cláudia Carvalho
Cristina Santos
Raquel Samões
Ricardo Martins-Ferreira
Catarina Teixeira
Diana Rodrigues
Joel Freitas
Carolina Lemos
Rui Chorão

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1512860

370 views

Original Research

Published on 12 Dec 2024

Excitatory neuron-prone prion propagation and excitatory neuronal loss in prion-infected mice

in Brain Disease Mechanisms

Temuulen Erdenebat
Yusuke Komatsu
Nozomi Uwamori
Misaki Tanaka
Takashi Hoshika
Takeshi Yamasaki
Ayano Shimakura
Akio Suzuki
Toyotaka Sato
Motohiro Horiuchi

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1498142

702 views

Review

Published on 11 Dec 2024

Chaperones vs. oxidative stress in the pathobiology of ischemic stroke

in Brain Disease Mechanisms

Vladislav Soldatov
Artem Venediktov
Andrei Belykh
Gennadii Piavchenko
Mukhammad David Naimzada
Nastasya Ogneva
Natalia Kartashkina
Olga Bushueva

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1513084

827 views

Original Research

Accepted on 10 Dec 2024

Uncovering novel KCC2 regulatory motifs through a comprehensive transposon-based mutant library

in Brain Disease Mechanisms

Pavel Uvarov
Satoshi Fudo
Cem Karakus
Andrey Golubtsov
Federico Rotondo
Tatiana Sukhanova
Shetal Soni
Coralie Di Scala
Tommi Kajander
Claudio Rivera

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1505722

171 views

Perspective

Published on 10 Dec 2024

Development of KCC2 therapeutics to treat neurological disorders

in Brain Disease Mechanisms

Shilpa D. Kadam
Shane V. Hegarty

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1503070

995 views

Original Research

Published on 05 Dec 2024

Transcorneal electrical stimulation restores DNA methylation changes in retinal degeneration

in Brain Disease Mechanisms

Ben Yi Tew
Gerald C. Gooden
Pei-An Lo
Dimitrios Pollalis
Brandon Ebright
Alex J. Kalfa
Alejandra Gonzalez-Calle
Biju Thomas
David N. Buckley
Thomas Simon

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1484964

598 views

Correction

Published on 04 Dec 2024

Corrigendum: Mechanisms of mitophagy and oxidative stress in cerebral ischemia–reperfusion, vascular dementia, and Alzheimer's disease

in Brain Disease Mechanisms

Yujie Lyu
Zhipeng Meng
Yunyun Hu
Bing Jiang
Jiao Yang
Yiqin Chen
Jun Zhou
Mingcheng Li
Huping Wang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1507345

351 views

Editorial

Published on 26 Nov 2024

Editorial: Antiviral drugs: neurotoxicity and neurodevelopmental effects

in Brain Disease Mechanisms

Isabella Zanella
Daniela Zizioli
Eugenia Quiros-Roldan
Aditya N. Bade

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1526357

394 views

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Articles

Serum metabolomic signatures of patients with rare neurogenetic diseases: an insight into potential biomarkers and treatment targets

Neurotherapeutic impact of vanillic acid and ibudilast on the cuprizone model of multiple sclerosis

The effect of AKT inhibition in α-synuclein-dependent neurodegeneration

Genetic and molecular mechanisms of hydrocephalus

Novel Strategies Targeting Mitochondria-Lysosome Contact Sites for the Treatment of Neurological Diseases

The role of Aha1 in cancer and neurodegeneration

Oxytosis/Ferroptosis: Unraveling the mechanisms and its multifaceted role in neurodegenerative diseases

Analysis of the pathogenicity and pathological characteristics of NOTCH3 gene-sparing cysteine mutations in vitro and in vivo models

Circulating miR-134 in mesial temporal lobe epilepsy: implications in hippocampal sclerosis development and drug resistance

Excitatory neuron-prone prion propagation and excitatory neuronal loss in prion-infected mice

Chaperones vs. oxidative stress in the pathobiology of ischemic stroke

Uncovering novel KCC2 regulatory motifs through a comprehensive transposon-based mutant library

Development of KCC2 therapeutics to treat neurological disorders

Transcorneal electrical stimulation restores DNA methylation changes in retinal degeneration

Corrigendum: Mechanisms of mitophagy and oxidative stress in cerebral ischemia–reperfusion, vascular dementia, and Alzheimer's disease

Editorial: Antiviral drugs: neurotoxicity and neurodevelopmental effects