Frontiers in Molecular Biosciences | Molecular Diagnostics and Therapeutics

Original Research

Published on 20 Feb 2025

Immunomagnetic enrichment coupled to PAX8/TP53 molecular pathology approach increases sensitivity in the detection of ovarian cancer cells in ascites

in Molecular Diagnostics and Therapeutics

Ivana Kurelac
Manuela Sollazzo
Monica De Luise
Francesca Nanetti
Laura Lanteri
Luigi D’Angelo
Beatrice Cavina
Simona Corrà
Stefano Miglietta
Sara Milioni

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1537407

Brief Research Report

Accepted on 19 Feb 2025

Determination of sample stability for a broad panel of coagulation parameters and factor assays on the Cobas t 711 analyzer starting from fresh-never-frozen plasma

in Molecular Diagnostics and Therapeutics

Michael Hoffmann
Norbert Gottschalk
Philipp Huber
Vanessa Scheling
Nicole von Allmen
Kolja Johannes Hegel

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1491239

Original Research

Accepted on 19 Feb 2025

LIMITED-RESOURCE COUNTRIES: COLLABORATING WITH EXPERT CENTERS FOR DIAGNOSIS OF PRIMARY CILIARY DYSKINESIA

in Molecular Diagnostics and Therapeutics

Mine Yüksel Kalyoncu
Rim Hjeij
Muruvvet Yanaz
Aynur Gulieva
Merve Selcuk Balcı
Şeyda Karabulut
Neval Metin Çakar
Almala Pınar Ergenekon
Ela Erdem Eralp
Yasemin Gökdemir

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1547152

Editorial

Published on 19 Feb 2025

Editorial: Experimental and computational methods in the development of diagnostics and therapeutics for colon cancer

in Molecular Diagnostics and Therapeutics

Muhammad Suleman
Shahid Ali
Farooq Rashid
Faez Iqbal Khan

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1568721

117 views

Original Research

Accepted on 17 Feb 2025

Integrative Multi-omics Analysis and Machine Learning Refine Global Histone Modification Features in Prostate Cancer

in Molecular Diagnostics and Therapeutics

Xiaofeng He
Qintao Ge
Wenyang Zhao
Yu Chao
Huiming Bai
Xiaotong Wu
Jing Tao
Wen-Hao Xu
Yunhua Qiu
Lei Chen

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1557843

Correction

Accepted on 17 Feb 2025

Corrigendum: Role of ARRB1 in prognosis and immunotherapy: A Pan-Cancer analysis

in Molecular Diagnostics and Therapeutics

Yingquan Ye
Haili Jiang
Yue Wu
Gaoxiang Wang
Yi Huang
Weijie Sun
Mei Zhang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1577764

Original Research

Accepted on 17 Feb 2025

Comparison of two immunotoxins against DLL3 receptor; as an inhibitor for Small Cell Lung Cancer

in Molecular Diagnostics and Therapeutics

Mohammad Hossein Ataee
Seyed Ali Mirhosseini
Reza Mirnejad
Hamideh Mahmoodzadeh Hosseini
Jafar Amani

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1506768

Original Research

Published on 17 Feb 2025

Genome-wide CRISPR/Cas9 screening identifies key profibrotic regulators of TGF-β1-induced epithelial-mesenchymal transformation and pulmonary fibrosis

in Molecular Diagnostics and Therapeutics

Chunjiang Tan
Juan Wang
Xiangrong Ye
Kaidirina Kasimu
Ye Li
Feng Luo
Hui Yi
Yifeng Luo

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1507163

367 views

Original Research

Published on 14 Feb 2025

An unfolded protein response (UPR)-signature regulated by the NFKB–miR-29b/c axis fosters tumor aggressiveness and poor survival in bladder cancer

in Molecular Diagnostics and Therapeutics

Jian Zhang
Xiaosong Fan
Yu Chen
Yichao Han
Weixing Yu
Shaolin Zhang
Bicheng Yang
Junlong Zhang
Yanling Chen

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1542650

198 views

Original Research

Published on 14 Feb 2025

A CRISPR-Cas-based recombinase polymerase amplification assay for ultra-sensitive detection of active Trypanosoma brucei evansi infections

in Molecular Diagnostics and Therapeutics

Andrés Álvarez-Rodríguez
Zeng Li
Bo-Kyung Jin
Benoit Stijlemans
Peter Geldhof
Stefan Magez

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1512970

435 views

Original Research

Published on 13 Feb 2025

Calcium-dependent adhesion protein CDH18, a potential biomarker for prognosis in uterine corpus endometrial carcinoma

in Molecular Diagnostics and Therapeutics

Xiaoxuan Tang
Shanxing Dang
Jie Qiu
Ruilan Zhou
Jing Ling
Limei Zhang
Xiaopeng Peng
Qingyun Li
Jin Liu
Wei Liao

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1530253

291 views

Editorial

Accepted on 12 Feb 2025

Editorial: Role of Fibroblast in Cancer

in Molecular Diagnostics and Therapeutics

Xuezhen Zeng
MAN LIU

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1574538

Original Research

Accepted on 12 Feb 2025

Rapamycin combined with Osimertinib alleviated non-small cell lung cancer by regulating the PARP, Akt/mTOR, and MAPK/ERK signaling pathways

in Molecular Diagnostics and Therapeutics

Qingrong Ma
Kai Chen
Haiping Xiao

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1548810

Original Research

Accepted on 11 Feb 2025

Multitargeted Biological Actions of Polydatin in Preventing Pseudogout Acute Attack

in Molecular Diagnostics and Therapeutics

Chiara Baggio
Paola Galozzi
Amelia Damasco
Vanni Lazzarin
Giampietro Ravagnan
Paolo Sfriso
Roberta Ramonda
Leonardo Punzi
Gianmaria Pennelli
Andrea Doria

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1553912

Original Research

Published on 11 Feb 2025

IL-6/GATA2/SERPINE1 pathway is implicated in regulating cellular senescence after acute kidney injury

in Molecular Diagnostics and Therapeutics

Hongshuang Su
Xiaoxi Lin
Ayinuer Paredong
Congcong Yao
Yan Zhang
Mengke Geng
Yuqian Guan
Lichao Gong
Feng Jiang
Qi Lv

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1538526

301 views

Original Research

Published on 11 Feb 2025

Homologous recombination deficiency test validation in patients with high-grade advanced ovarian cancer

in Molecular Diagnostics and Therapeutics

Angelica Nogueira Rodrigues
Andreza Karine de Barros Almeida Souto
Diocésio Alves Pinto de Andrade
Larissa Müller Gomes
Sandra Satie Koide
Renata de Godoy e Silva
Bruno Batista de Souza
Juliana Doblas Massaro
Andréia Cristina de Melo
Andrea Morais Borges

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1524594

258 views

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Articles

Immunomagnetic enrichment coupled to PAX8/TP53 molecular pathology approach increases sensitivity in the detection of ovarian cancer cells in ascites

Determination of sample stability for a broad panel of coagulation parameters and factor assays on the Cobas t 711 analyzer starting from fresh-never-frozen plasma

LIMITED-RESOURCE COUNTRIES: COLLABORATING WITH EXPERT CENTERS FOR DIAGNOSIS OF PRIMARY CILIARY DYSKINESIA

Editorial: Experimental and computational methods in the development of diagnostics and therapeutics for colon cancer

Integrative Multi-omics Analysis and Machine Learning Refine Global Histone Modification Features in Prostate Cancer

Corrigendum: Role of ARRB1 in prognosis and immunotherapy: A Pan-Cancer analysis

Comparison of two immunotoxins against DLL3 receptor; as an inhibitor for Small Cell Lung Cancer

Genome-wide CRISPR/Cas9 screening identifies key profibrotic regulators of TGF-β1-induced epithelial-mesenchymal transformation and pulmonary fibrosis

An unfolded protein response (UPR)-signature regulated by the NFKB–miR-29b/c axis fosters tumor aggressiveness and poor survival in bladder cancer

A CRISPR-Cas-based recombinase polymerase amplification assay for ultra-sensitive detection of active Trypanosoma brucei evansi infections

Calcium-dependent adhesion protein CDH18, a potential biomarker for prognosis in uterine corpus endometrial carcinoma

Editorial: Role of Fibroblast in Cancer

Rapamycin combined with Osimertinib alleviated non-small cell lung cancer by regulating the PARP, Akt/mTOR, and MAPK/ERK signaling pathways

Multitargeted Biological Actions of Polydatin in Preventing Pseudogout Acute Attack

IL-6/GATA2/SERPINE1 pathway is implicated in regulating cellular senescence after acute kidney injury

Homologous recombination deficiency test validation in patients with high-grade advanced ovarian cancer