Frontiers in Molecular Biosciences | Molecular Diagnostics and Therapeutics

Original Research

Published on 11 Feb 2025

IL-6/GATA2/SERPINE1 pathway is implicated in regulating cellular senescence after acute kidney injury

in Molecular Diagnostics and Therapeutics

Hongshuang Su
Xiaoxi Lin
Ayinuer Paredong
Congcong Yao
Yan Zhang
Mengke Geng
Yuqian Guan
Lichao Gong
Feng Jiang
Qi Lv

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1538526

Original Research

Published on 11 Feb 2025

Homologous recombination deficiency test validation in patients with high-grade advanced ovarian cancer

in Molecular Diagnostics and Therapeutics

Angelica Nogueira Rodrigues
Andreza Karine de Barros Almeida Souto
Diocésio Alves Pinto de Andrade
Larissa Müller Gomes
Sandra Satie Koide
Renata de Godoy e Silva
Bruno Batista de Souza
Juliana Doblas Massaro
Andréia Cristina de Melo
Andrea Morais Borges

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1524594

Review

Accepted on 10 Feb 2025

FOXOs and their roles in acute and chronic neurological disorders

in Molecular Diagnostics and Therapeutics

Yasin Asadi
Rozenn K Moundounga
Anand Chakroborty
Augustina Pokokiri
Hongmin Wang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1538472

Original Research

Accepted on 07 Feb 2025

Development of an Enzyme-Linked Immunosorbent Assay (ELISA) for Determining Neutrophil Elastase (NE) -a Potential Useful Marker of Multi-organ Damage Observed in COVID-19 and Post-Covid-19 (PCS)

in Molecular Diagnostics and Therapeutics

Joanna Adamiec-Mroczek
Joanna Kluz
Sandra Chwałek
Maciej Rabczyński
Kinga Gostomska-Pampuch
Łukasz Lewandowski
Marta Misiuk-Hojło
Beata Ponikowska
Goutam Chourasia
Ilias Dumas

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1542898

100 views

Original Research

Published on 07 Feb 2025

Defining the high-risk category of patients with cutaneous melanoma: a practical tool based on prognostic modeling

in Molecular Diagnostics and Therapeutics

Oleksandr Dudin
Ozar Mintser
Vitalii Gurianov
Nazarii Kobyliak
Denys Kozakov
Sofiia Livshun
Oksana Sulaieva

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1543148

217 views

Original Research

Published on 07 Feb 2025

Serum glutathione peroxidase-3 concentration at diagnosis as a biomarker for assessing disease activity and damage of antineutrophil cytoplasmic antibody-associated vasculitis at diagnosis

in Molecular Diagnostics and Therapeutics

Jihye Chung
Jang Woo Ha
Yong-Beom Park
Sang-Won Lee

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1549454

187 views

Original Research

Published on 06 Feb 2025

Deciphering the role of miRNA-mRNA interactions in cerebral vasospasm post intracranial hemorrhage

in Molecular Diagnostics and Therapeutics

Xiang Chu
Xiyan Zhu
Honghao Xu
Wenbing Zhao
Debin Guo
Xing Chen
Jinze Wu
Lei Li
Hao Wang
Jun Fei

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1492729

191 views

Review

Published on 06 Feb 2025

The diagnostic and prognostic significance of HOXC13-AS and its molecular regulatory mechanism in human cancer

in Molecular Diagnostics and Therapeutics

Xiaosi Gu
Xin Hu
Sijia Zhang
Xiaoyu Zhang
Yong Wang
Lianlian Li

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1540048

139 views

Brief Research Report

Accepted on 05 Feb 2025

Pilot study: a descriptive-retrospective analysis of SARS-CoV-2 variants distribution and phylogenesis in the Phlegraean Area

in Molecular Diagnostics and Therapeutics

Maria Cristina Mazzarella
Stefano Cristiano
Dilia Rea
Nicola Mazzarella
Martina Addeo
Silvia Ianelli
Geppino Falco
Mariarita Brancaccio
Tiziana Angrisano

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1536953

Review

Published on 04 Feb 2025

The role of potential oxidative biomarkers in the prognosis of intracerebral hemorrhage and the exploration antioxidants as possible preventive and treatment options

in Molecular Diagnostics and Therapeutics

Jiayong Yao
Xiaohong Dai
Xueping Yv
Lei Zheng
Jia Zheng
Binglin Kuang
Wei Teng
Weiwei Yu
Mingyue Li
Hongtao Cao

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1541230

239 views

Original Research

Published on 03 Feb 2025

Potential biomarkers and immune infiltration linking endometriosis with recurrent pregnancy loss based on bioinformatics and machine learning

in Molecular Diagnostics and Therapeutics

Jianhui Chen
Qun Li
Xiaofang Liu
Fang Lin
Yaling Jing
Jiayan Yang
Lianfang Zhao

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1529507

256 views

Hypothesis and Theory

Accepted on 31 Jan 2025

Jianpi Yangzheng Xiaozheng granule induced ferroptosis to suppress gastric cancer progression through reprogramming lipid metabolism via SCD1/Wnt/β-catenin axis

in Molecular Diagnostics and Therapeutics

Xiangyang Wang
Jingxiao Li
Rong Qin
Yi Yin
Jiepin Li
Sitian Lin
Xi Zou

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1523494

102 views

Review

Published on 31 Jan 2025

Epigenetic regulation in coronary artery disease: from mechanisms to emerging therapies

in Molecular Diagnostics and Therapeutics

Rui Gao
Meilin Liu
Haoyi Yang
Yuhan Shen
Ni Xia

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1548355

241 views

Original Research

Accepted on 30 Jan 2025

Q-Der: A Next-Generation CoQ10 Analogue Supercharging Neuroprotection by Combating Oxidative Stress and Enhancing Mitochondrial Function

in Molecular Diagnostics and Therapeutics

Michela Battistelli
Matteo Micucci
Federico Gianfanti
Sabrina DONATI ZEPPA
Giosuè Annibalini
BARBARA CANONICO
fabiana fanelli
ROBERTA SALTARELLI
riham osman
mariele montanari

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1525103

Original Research

Accepted on 30 Jan 2025

Identifying potential biomarkers and molecular mechanisms related to arachidonic acid metabolism in vitiligo

in Molecular Diagnostics and Therapeutics

Lijun Sun
Xiaoqing Li
Li Yang
Longfei Zhu
Jingying Sun
Xu Cuixiang

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1536477

Original Research

Published on 30 Jan 2025

Sotorasib resistance triggers epithelial-mesenchymal transition and activates AKT and P38-mediated signaling

in Molecular Diagnostics and Therapeutics

Raquel Arantes Megid
Guilherme Gomes Ribeiro
Izabela Natalia Faria Gomes
Ana Carolina Laus
Letícia Ferro Leal
Luciane Sussuchi da Silva
Abu-Bakr Adetayo Ariwoola
Josiane Mourão Dias
Rui Manuel Reis
Renato Jose da Silva-Oliveira

Frontiers in Molecular Biosciences

doi 10.3389/fmolb.2025.1537523

403 views

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Articles

IL-6/GATA2/SERPINE1 pathway is implicated in regulating cellular senescence after acute kidney injury

Homologous recombination deficiency test validation in patients with high-grade advanced ovarian cancer

FOXOs and their roles in acute and chronic neurological disorders

Development of an Enzyme-Linked Immunosorbent Assay (ELISA) for Determining Neutrophil Elastase (NE) -a Potential Useful Marker of Multi-organ Damage Observed in COVID-19 and Post-Covid-19 (PCS)

Defining the high-risk category of patients with cutaneous melanoma: a practical tool based on prognostic modeling

Serum glutathione peroxidase-3 concentration at diagnosis as a biomarker for assessing disease activity and damage of antineutrophil cytoplasmic antibody-associated vasculitis at diagnosis

Deciphering the role of miRNA-mRNA interactions in cerebral vasospasm post intracranial hemorrhage

The diagnostic and prognostic significance of HOXC13-AS and its molecular regulatory mechanism in human cancer

Pilot study: a descriptive-retrospective analysis of SARS-CoV-2 variants distribution and phylogenesis in the Phlegraean Area

The role of potential oxidative biomarkers in the prognosis of intracerebral hemorrhage and the exploration antioxidants as possible preventive and treatment options

Potential biomarkers and immune infiltration linking endometriosis with recurrent pregnancy loss based on bioinformatics and machine learning

Jianpi Yangzheng Xiaozheng granule induced ferroptosis to suppress gastric cancer progression through reprogramming lipid metabolism via SCD1/Wnt/β-catenin axis

Epigenetic regulation in coronary artery disease: from mechanisms to emerging therapies

Q-Der: A Next-Generation CoQ10 Analogue Supercharging Neuroprotection by Combating Oxidative Stress and Enhancing Mitochondrial Function

Identifying potential biomarkers and molecular mechanisms related to arachidonic acid metabolism in vitiligo

Sotorasib resistance triggers epithelial-mesenchymal transition and activates AKT and P38-mediated signaling