Skip to main content

ORIGINAL RESEARCH article

Front. Mol. Biosci.

Sec. Molecular Diagnostics and Therapeutics

Volume 12 - 2025 | doi: 10.3389/fmolb.2025.1558495

This article is part of the Research Topic Application of Deep Learning in Biomedical Image Processing View all articles

LT-YOLO: Long-term Temporal Enhanced YOLO for Stenosis Detection on Invasive Coronary Angiography

Provisionally accepted
Jiaxin Li Jiaxin Li 1,2*Xiang Tang Xiang Tang 2Xuesong Wang Xuesong Wang 3
  • 1 Sun Yat-sen University, Guangzhou, China
  • 2 School of Biomedical Engineering, Sun Yat-sen University, Shenzhen, China
  • 3 College of Mining Engineering, University of Science and Technology Liaoning, Anshan, China

The final, formatted version of the article will be published soon.

    Coronary artery stenosis detection on Invasive Coronary Angiography plays a pivotal role in computer-aided diagnosis and treatment. However, it faces the challenge of stenotic morphology confusion stemmed from coronary-background similarity, varied morphology and small area of the stenosis. Furthermore, existing automated methods ignore the long-temporal information mining. To address these limitations, this paper proposes a Long-term Temporal Enhanced YOLO for automatic stenosis detection and assessment in Invasive Coronary Angiography. Our approach integrates longterm temporal information and spatial information for stenosis detection with state space models and YOLOv8. First, a spatial-aware backbone based on dynamic transformer and C2f Convolution of YOLOv8 combines the local and global feature extraction to distinguish the coronary regions from the background. Second, a spatial-temporal multi-level fusion neck integrates the long-term temporal and spatial features to handle varied stenotic morphology. Third, a detail-aware detection head leverages low-level information for accurate identification of small stenosis. Extensive experiments on 350 ICA video sequences demonstrate the model's superior performance over seven state-of-the-art methods, particularly in detecting small stenosis (percentage less than 50%), which was previously underexplored.

    Keywords: Coronary Artery Disease, Stenosis detection, State space model, Mamba, YOLO

    Received: 10 Jan 2025; Accepted: 25 Feb 2025.

    Copyright: © 2025 Li, Tang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jiaxin Li, Sun Yat-sen University, Guangzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

    Research integrity at Frontiers

    Man ultramarathon runner in the mountains he trains at sunset

    94% of researchers rate our articles as excellent or good

    Learn more about the work of our research integrity team to safeguard the quality of each article we publish.


    Find out more