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REVIEW article

Front. Mol. Biosci.
Sec. Cellular Biochemistry
Volume 11 - 2024 | doi: 10.3389/fmolb.2024.1480617

The function of Nicotinamide phosphoribosyl transferase (NAMPT) and its role in diseases

Provisionally accepted
Aihong Peng Aihong Peng Junqin Li Junqin Li Jianxiao Xing Jianxiao Xing Yuanjun Yao Yuanjun Yao Xuping Niu Xuping Niu Kaiming Zhang Kaiming Zhang *
  • ShanXi Key Laboratory of Stem Cells for Immunological Dermatosis, Taiyuan, China

The final, formatted version of the article will be published soon.

    Nicotinamide phosphoribosyl transferase (NAMPT) is a rate-limiting enzyme in the mammalian nicotinamide adenine dinucleotide (NAD) salvage pathway, and plays a vital role in the regulation of cell metabolic activity, reprogramming, aging and apoptosis. NAMPT synthesizes nicotinamide mononucleotide (NMN) through enzymatic action, which is a key protein involved in host defense mechanism and plays an important role in metabolic homeostasis and cell survival. NAMPT is involved in NAD metabolism and maintains intracellular NAD levels. Sirtuins (SIRTs) are a family of nicotinamide adenine dinucleotide (NAD)-dependent histone deacetylases (HDACs), the members are capable of sensing cellular NAD+ levels. NAMPT-NAD and SIRT constitute a powerful anti-stress defense system. In this paper, the structure, biological function and correlation with diseases of NAMPT are introduced, aiming to provide new ideas for the targeted therapy of related diseases.

    Keywords: NAMPT, NAD metabolism, biological function, SIRTs, Diseases

    Received: 14 Aug 2024; Accepted: 11 Oct 2024.

    Copyright: © 2024 Peng, Li, Xing, Yao, Niu and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Kaiming Zhang, ShanXi Key Laboratory of Stem Cells for Immunological Dermatosis, Taiyuan, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.