XuWen Zheng
MaoBing Chen
*The final, formatted version of the article will be published soon.
ORIGINAL RESEARCH article
Front. Microbiol.
Sec. Microorganisms in Vertebrate Digestive Systems
Volume 15 - 2024 |
doi: 10.3389/fmicb.2024.1448629
This article is part of the Research Topic Early-life Gut Microbiota Perturbations and its Impacts on Host Health and Disease: From Underlying Mechanisms to Therapeutic Opportunities View all 7 articles
Unveiling Genetic Links Between Gut Microbiota and Asthma: A
Provisionally accepted- Changzhou Wujin People's Hospital, Changning, China
Background Multiple studies suggest a potential connection between the gut microbiome and asthma. Our objective is to use advanced genetic and metagenomic techniques to elucidate the causal relationships and underlying mechanisms between gut microbiota and asthma. Methods The study utilized comprehensive Linkage Disequilibrium Score Regression (LDSC) and Mendelian Randomization (MR) analyses to examine the relationship between 119 gut microbiota genera and asthma, using publicly accessible genome-wide association studies (GWAS). The meta-analysis synthesized summary effect estimates obtained from LDSC, forward MR, and reverse MR. The MiBioGen collaboration, involving 18,340 individuals, identified genetic variations associated with gut bacteria. Asthma data were collected from the UK Biobank, FinnGen, and GERA, encompassing a total of 82,060 cases and 641,049 controls. Results LDSC analysis revealed significant negative genetic correlations between asthma and RuminococcaceaeUCG004 (Rg = -0.55, P = 7.66×10 -5 ) and Subdoligranulum (Rg = -0.35, P = 3.61×10 -4 ). Forward MR analysis suggested associations between Butyricicoccus (OR = 0.92, P = 0.01), Turicibacter (OR = 0.95, P = 0.025), Butyrivibrio (OR = 0.98, P = 0.047), and reduced asthma risk. Conversely, Coprococcus2 (OR = 1.10, P = 0.035) and Roseburia (OR = 1.07, P = 0.039) were associated with increased risk. Reverse MR analysis indicated significant associations between genetically predicted asthma and Eubacteriumxylanophilumgroup (Beta = -0.08, P = 9.25×10 -7 ), LachnospiraceaeNK4A136group (Beta = -0.05, P = 1.26×10 -4 ), and Eisenbergiella (Beta = 0.06, P = 0.015, Rg_P = 0.043).The findings underscore significant genetic correlations and causal relationships between specific gut microbiota and asthma. These insights highlight the potential of gut microbiota as both markers and modulators of asthma risk, offering new avenues for targeted therapeutic strategies.
Keywords: Asthma, Gut Microbiota, linkage disequilibrium score regression, Mendelian randomization, Meta-analysis 1 Introduction
Received: 13 Jun 2024; Accepted: 09 Sep 2024.
Copyright: © 2024 Zheng, Chen, Zhuang, Zhao, Qian and Shi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
MaoBing Chen, Changzhou Wujin People's Hospital, Changning, China
Yi Zhuang, Changzhou Wujin People's Hospital, Changning, China
Liang Zhao, Changzhou Wujin People's Hospital, Changning, China
Yongjun Qian, Changzhou Wujin People's Hospital, Changning, China
ChengCheng Shi, Changzhou Wujin People's Hospital, Changning, China
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