Skip to main content

ORIGINAL RESEARCH article

Front. Microbiol.
Sec. Microorganisms in Vertebrate Digestive Systems
Volume 15 - 2024 | doi: 10.3389/fmicb.2024.1410624

Causal relationships between gut microbiome and obstructive sleep apnea: A bi-directional Mendelian randomization

Provisionally accepted
Liangfeng Liu Liangfeng Liu 1Guanwen He Guanwen He 1*Rong Yu Rong Yu 2*Bingbang Lin Bingbang Lin 1*Liangqing Lin Liangqing Lin 1*Rifu Wei Rifu Wei 1*Zhongshou Zhu Zhongshou Zhu 1*Yangbin Xu Yangbin Xu 1*
  • 1 Ningde Municipal Hospital of Ningde Normal University, Ningde, Fujian, China
  • 2 Jiaocheng District Maternal and Child Health Hospital, Ningde, China

The final, formatted version of the article will be published soon.

    Background: Previous studies have identified a clinical association between gut microbiota and Obstructive sleep apnea (OSA), but the potential causal relationship between the two has not been determined. Therefore, we aim to utilize Mendelian randomization (MR) to investigate the potential causal effects of gut microbiota on OSA and the impact of OSA on altering the composition of gut microbiota.: Bi-directional MR and replicated validation were utilized. Summary-level genetic data of gut microbiota were derived from the MiBioGen consortium and the Dutch Microbiome Project (DMP). Summary statistics of OSA were drawn from FinnGen Consortium and Million Veteran Program (MVP). Inverse-variance-weighted (IVW), weighted median, MR-Egger, Simple Mode, and Weighted Mode methods were used to evaluate the potential causal link between gut microbiota and OSA. Results: We identified potential causal associations between 23 gut microbiota and OSA. Among them, genus Eubacterium xylanophilum group (OR= 0.86; P = 0.00013), Bifidobacterium longum (OR= 0.90; P = 0.0090), Parabacteroides merdae (OR= 0.85; P = 0.00016) retained a strong negative association with OSA after the Bonferroni correction. Reverse MR analyses indicated that OSA was associated with 20 gut microbiota, among them, a strong inverse association between OSA and genus Anaerostipes (beta= -0.35; P = 0.00032) was identified after Bonferroni correction.Our study implicates the potential bi-directional causal effects of the gut microbiota on OSA, potentially providing new insights into the prevention and treatment of OSA through specific gut microbiota.

    Keywords: Causal effect, Gut Microbiota, Mendelian randomization, obstructive sleep apnea, risk factor

    Received: 07 Jun 2024; Accepted: 25 Jul 2024.

    Copyright: © 2024 Liu, He, Yu, Lin, Lin, Wei, Zhu and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Guanwen He, Ningde Municipal Hospital of Ningde Normal University, Ningde, Fujian, China
    Rong Yu, Jiaocheng District Maternal and Child Health Hospital, Ningde, China
    Bingbang Lin, Ningde Municipal Hospital of Ningde Normal University, Ningde, Fujian, China
    Liangqing Lin, Ningde Municipal Hospital of Ningde Normal University, Ningde, Fujian, China
    Rifu Wei, Ningde Municipal Hospital of Ningde Normal University, Ningde, Fujian, China
    Zhongshou Zhu, Ningde Municipal Hospital of Ningde Normal University, Ningde, Fujian, China
    Yangbin Xu, Ningde Municipal Hospital of Ningde Normal University, Ningde, Fujian, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.