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ORIGINAL RESEARCH article

Front. Microbiol.
Sec. Microorganisms in Vertebrate Digestive Systems
Volume 15 - 2024 | doi: 10.3389/fmicb.2024.1381423
This article is part of the Research Topic Gut Microbiota Modulation to Mitigate Stress-Induced Functional Changes View all 3 articles

Stress-induced obesity in mice causes cognitive decline associated with inhibition of hippocampal neurogenesis and dysfunctional gut microbiota

Provisionally accepted
Jinqiang Zhang Jinqiang Zhang 1*Yu-E Liu Yu-E Liu 1Zhihuang Zhao Zhihuang Zhao 1Haili He Haili He 1Liangyuan Li Liangyuan Li 1Chenghong Xiao Chenghong Xiao 1Tao Zhou Tao Zhou 1*Zili You Zili You 2*
  • 1 Guizhou University of Traditional Chinese Medicine, Guiyang, China
  • 2 University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China

The final, formatted version of the article will be published soon.

    1. Chronic stress can induce diet-independent obesity in mice.2. Stress-induced obesity involves alterations in the gut microbiome and hyperactivation of the hypothalamic-pituitary-adrenal axis.In brief: Liu et al. provide evidence from a mouse model that chronic stress can induce dietindependent obesity and cognitive deficits involving hyperactive hypothalamic-pituitary-adrenal signaling, hyperactive microglia, impaired neurogenesis, systemic inflammation, and alterations in the gut microbiome. Mitigating one or more of these processes may ameliorate the stress-induced 2 cognitive deficits and obesity.

    Keywords: stress, Obesity, Depression, Cognitive Function, gut microbiome, Adult hippocampus neurogenesis, Microglia Abbreviations ACTH, adrenocorticotropin, CRH, corticotropin-releasing hormone

    Received: 03 Feb 2024; Accepted: 16 Oct 2024.

    Copyright: © 2024 Zhang, Liu, Zhao, He, Li, Xiao, Zhou and You. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Jinqiang Zhang, Guizhou University of Traditional Chinese Medicine, Guiyang, China
    Tao Zhou, Guizhou University of Traditional Chinese Medicine, Guiyang, China
    Zili You, University of Electronic Science and Technology of China, Chengdu, 611731, Sichuan Province, China

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