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ORIGINAL RESEARCH article
Front. Microbiol.
Sec. Microorganisms in Vertebrate Digestive Systems
Volume 15 - 2024 |
doi: 10.3389/fmicb.2024.1381423
This article is part of the Research Topic Gut Microbiota Modulation to Mitigate Stress-Induced Functional Changes View all 3 articles
Stress-induced obesity in mice causes cognitive decline associated with inhibition of hippocampal neurogenesis and dysfunctional gut microbiota
Provisionally accepted- 1 Guizhou University of Traditional Chinese Medicine, Guiyang, China
- 2 University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China
1. Chronic stress can induce diet-independent obesity in mice.2. Stress-induced obesity involves alterations in the gut microbiome and hyperactivation of the hypothalamic-pituitary-adrenal axis.In brief: Liu et al. provide evidence from a mouse model that chronic stress can induce dietindependent obesity and cognitive deficits involving hyperactive hypothalamic-pituitary-adrenal signaling, hyperactive microglia, impaired neurogenesis, systemic inflammation, and alterations in the gut microbiome. Mitigating one or more of these processes may ameliorate the stress-induced 2 cognitive deficits and obesity.
Keywords: stress, Obesity, Depression, Cognitive Function, gut microbiome, Adult hippocampus neurogenesis, Microglia Abbreviations ACTH, adrenocorticotropin, CRH, corticotropin-releasing hormone
Received: 03 Feb 2024; Accepted: 16 Oct 2024.
Copyright: © 2024 Zhang, Liu, Zhao, He, Li, Xiao, Zhou and You. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jinqiang Zhang, Guizhou University of Traditional Chinese Medicine, Guiyang, China
Tao Zhou, Guizhou University of Traditional Chinese Medicine, Guiyang, China
Zili You, University of Electronic Science and Technology of China, Chengdu, 611731, Sichuan Province, China
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