AUTHOR=Liu Yu-e , Zhao Zhihuang , He Haili , Li Liangyuan , Xiao Chenghong , Zhou Tao , You Zili , Zhang Jinqiang 

TITLE=Stress-induced obesity in mice causes cognitive decline associated with inhibition of hippocampal neurogenesis and dysfunctional gut microbiota

JOURNAL=Frontiers in Microbiology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2024.1381423

DOI=10.3389/fmicb.2024.1381423

ISSN=1664-302X

ABSTRACT=<p>1. Chronic stress can induce diet-independent obesity in mice.2. Stress-induced obesity involves alterations in the gut microbiome and hyperactivation of the hypothalamic-pituitary-adrenal axis.In brief: Liu et al. provide evidence from a mouse model that chronic stress can induce dietindependent obesity and cognitive deficits involving hyperactive hypothalamic-pituitary-adrenal signaling, hyperactive microglia, impaired neurogenesis, systemic inflammation, and alterations in the gut microbiome. Mitigating one or more of these processes may ameliorate the stress-induced 2 cognitive deficits and obesity.</p>