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ORIGINAL RESEARCH article

Front. Med.
Sec. Geriatric Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1491584
This article is part of the Research Topic Biological Markers of Healthy Aging View all articles

Handgrip Strength as a Potential Indicator of Ageing: Insights from Its Association with Ageing-Related Laboratory Parameters

Provisionally accepted
Nina Kemala Sari Nina Kemala Sari 1*Stepvia Stepvia Stepvia Stepvia 1Muhana Fawwazy Ilyas Muhana Fawwazy Ilyas 2Siti Setiati Siti Setiati 1Kuntjoro Harimurti Kuntjoro Harimurti 1Ika Fitriana Ika Fitriana 1
  • 1 Geriatric Division, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
  • 2 Faculty of medicine, Universitas Sebelas Maret, Surakarta, Indonesia

The final, formatted version of the article will be published soon.

    The ageing process is frequently linked to a decline in functional capacity and endurance, including a decrease in muscle quality and overall quality of life. Examining ageing-related biomarkers necessitates a lengthy examination period and may incur significant financial expenses. Consequently, we require a straightforward indicator to describe ageing-related factors efficiently. This study aims to investigate the association between handgrip strength and ageing-related laboratory parameters in the elderly population of Indonesia. This cross-sectional study comprised 109 participants aged between 60 and 82. The measurement of handgrip strength was conducted using a Jamar hydraulic hand dynamometer and Jamar PLUS+ digital dynamometer. The ageing-related laboratory parameters biomarker is defined as a biomarker that can indicate the ageing process. Our study demonstrates a significant association between leukocyte, neutrophil absolute, lymphocyte absolute, neutrophil/lymphocyte ratio, and erythrocyte sedimentation rate with handgrip strength. In conclusion, this study identifies an association between handgrip strength and ageing-related laboratory parameters. These findings suggest that handgrip strength could serve as an effective and practical predictor of ageing-related health status in older adults, highlighting its potential as a cost-effective, non-invasive tool for assessing the physiological impacts of ageing and guiding health interventions in the elderly population.

    Keywords: Ageing, biomarkers, elderly population, functional capacity, handgrip strength

    Received: 05 Sep 2024; Accepted: 13 Jan 2025.

    Copyright: © 2025 Kemala Sari, Stepvia, Ilyas, Setiati, Harimurti and Fitriana. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Nina Kemala Sari, Geriatric Division, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.