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CASE REPORT article
Front. Med.
Sec. Pulmonary Medicine
Volume 11 - 2024 |
doi: 10.3389/fmed.2024.1479877
Alpha-1 antitrypsin: Augmentation therapy in pregnancy
Provisionally accepted
Anna Annunziata
1,2
Giuseppe Fiorentino
1,2
Antonietta Coppola
1,2*
Rosa Cauteruccio
1,2
Laura Ferrentino
1,2
Luigi Fiorentino
1,2
Cecilia Calabrese
1,2- 1 UOC respiratory pathophisiology and rehabilitation, Naples, Campania, Italy
- 2 Hospital of the Hills, Naples, Italy
Alpha-1 antitrypsin deficiency (AATD) is an inherited condition characterized by reduced plasma levels of alpha-1 antitrypsin (AAT), often leading to pulmonary diseases primarily emphysema and/or chronic obstructive pulmonary disease (COPD), but also bronchiectasis, bronchial asthma or other less common disorders. Early diagnosis enables AAT augmentation therapy, which has proven to be effective in slowing down functional decline and improving survival rates. This paper presents two cases of pregnant women with rare allelic variants of AATD who received AAT augmentation therapy, exploring the limited evidence on its safety during pregnancy and the potential role of decreased serum AAT levels in pregnancy-related complications.
Keywords: alpha-1 antitrypsin deficiency, Pregnancy, augmentation therapy, Emphysema, Safety
Received: 12 Aug 2024; Accepted: 11 Nov 2024.
Copyright: © 2024 Annunziata, Fiorentino, Coppola, Cauteruccio, Ferrentino, Fiorentino and Calabrese. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Antonietta Coppola, Hospital of the Hills, Naples, Italy
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