AUTHOR=Annunziata Anna , Fiorentino Giuseppe , Coppola Antonietta , Cauteruccio Rosa , Ferrentino Laura , Fiorentino Luigi , Calabrese Cecilia 

TITLE=Alpha-1 antitripsyn deficiency and augmentation therapy in pregnancy: two case reports

JOURNAL=Frontiers in Medicine

VOLUME=Volume 11 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1479877

DOI=10.3389/fmed.2024.1479877

ISSN=2296-858X

ABSTRACT=<p>Alpha-1 antitrypsin deficiency (AATD) is an inherited condition characterized by reduced plasma levels of alpha-1 antitrypsin (AAT), often leading to pulmonary diseases primarily emphysema and/or chronic obstructive pulmonary disease (COPD), but also bronchiectasis, bronchial asthma, or other less common disorders. Early diagnosis enables AAT augmentation therapy, which has proven to be effective in slowing down functional decline and improving survival rates. This article presents two cases of pregnant women with rare allelic variants of AATD who received AAT augmentation therapy, exploring the limited evidence on its safety during pregnancy and the potential role of decreased serum AAT levels in pregnancy-related complications.</p>