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ORIGINAL RESEARCH article

Front. Med.
Sec. Nuclear Medicine
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1464779
This article is part of the Research Topic Advances in PET-CT Imaging View all 11 articles

Impact of fat intake on [ 18 F]AlF-NOTA-FAPI-04 uptake in normal abdominal organs

Provisionally accepted
Jiashun Dai Jiashun Dai 1*Wanjing Zhou Wanjing Zhou 1*Huaping Liu Huaping Liu 2*Chengzhi Jiang Chengzhi Jiang 1Hui Ye Hui Ye 1*
  • 1 Department of PET-CT Center, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University / Hunan Cancer Hospital, Changsha, China
  • 2 Department of Radiology, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, China

The final, formatted version of the article will be published soon.

    Purpose: [ 18 F]AlF-NOTA-FAPI-04 demonstrates significant physiological uptake in the gallbladder and biliary tract system, representing a limitation of this positron emission tomography(PET) tracer. The aim of this study was to evaluate the impact of milk consumed prior to a PET/CT scan on [ 18 F]AlF-NOTA-FAPI-04 uptake in normal abdominal organs.A total of 86 patients who underwent [ 18 F]AlF-NOTA-FAPI-04 PET/CT imaging took part in this single-center retrospective clinical study at the Hunan Cancer Hospital between December 2020 and August 2021. Patients were divided into two groups according to their pre-PET scan diet: treated group, who consumed 250ml of milk 10±5minutes after the tracer injection, while the control group was permitted no food intake subsequent to the radiotracer administration. The mean standardized uptake value (SUVmean) of gallbladder, liver, small intestine and pancreas were measured in 18 F-FAPI and 18 F-FDG PET/CT.Results: There was a statistically significant difference in the 18 F-FAPI uptake in the gallbladder between the treated group and the control group (P <0.001). The average SUVmean in the treated group was 2.19±2.01 , which was significantly lower than the average SUVmean of 10.04±9.66 in the control group. In the subgroup analysis of patients who underwent paired [ 18 F]FDG and [ 18 F]FAPI PET/CT scans, the 18 F-FAPI uptake of liver and small intestine was significantly lower than the 18 F-FDG uptake in both the treated group and the control group(P <0.001).This study suggests that milk consumption decreases physiological 18 F-FAPI uptake in the gallbladder, potentially enhancing the diagnostic accuracy for gallbladder cancer.

    Keywords: Milk, [ 18 F]AlF-NOTA-FAPI-04, positron emission tomography, Gallbladder, SUVmean

    Received: 15 Jul 2024; Accepted: 28 Oct 2024.

    Copyright: © 2024 Dai, Zhou, Liu, Jiang and Ye. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Jiashun Dai, Department of PET-CT Center, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University / Hunan Cancer Hospital, Changsha, China
    Wanjing Zhou, Department of PET-CT Center, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University / Hunan Cancer Hospital, Changsha, China
    Huaping Liu, Department of Radiology, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, China
    Hui Ye, Department of PET-CT Center, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University / Hunan Cancer Hospital, Changsha, China

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