AUTHOR=Dai Jiashun , Zhou Wanjing , Liu Huaping , Jiang Chengzhi , Ye Hui 

TITLE=Impact of fat intake on [18F]AlF-NOTA-FAPI-04 uptake in normal abdominal organs

JOURNAL=Frontiers in Medicine

VOLUME=11

YEAR=2024

URL=https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2024.1464779

DOI=10.3389/fmed.2024.1464779

ISSN=2296-858X

ABSTRACT=<sec id="sec1"><title>Purpose</title><p>[<sup>18</sup>F]AlF-NOTA-FAPI-04 demonstrates significant physiological uptake in the gallbladder and biliary tract system, representing a limitation of this positron emission tomography (PET) tracer. The aim of this study was to evaluate the impact of milk consumed prior to a PET/CT scan on [<sup>18</sup>F]AlF-NOTA-FAPI-04 uptake in normal abdominal organs.</p></sec><sec id="sec2"><title>Materials and methods</title><p>A total of 86 patients who underwent [<sup>18</sup>F]AlF-NOTA-FAPI-04 PET/CT imaging took part in this single-center retrospective clinical study at the Hunan Cancer Hospital between December 2020 and August 2021. Patients were divided into two groups according to their pre-PET scan diet: treated group, who consumed 250 mL of milk 10 ± 5 min after the tracer injection, while the control group was permitted no food intake subsequent to the radiotracer administration. The mean standardized uptake value (SUV<sub>mean</sub>) of gallbladder, liver, small intestine and pancreas were measured in <sup>18</sup>F-FAPI and <sup>18</sup>F-FDG PET/CT.</p></sec><sec id="sec3"><title>Results</title><p>There was a statistically significant difference in the <sup>18</sup>F-FAPI uptake in the gallbladder between the treated group and the control group (<italic>p</italic> &lt; 0.001). The average SUV<sub>mean</sub> in the treated group was 2.19 ± 2.01, which was significantly lower than the average SUV<sub>mean</sub> of 10.04 ± 9.66 in the control group. In the subgroup analysis of patients who underwent paired [<sup>18</sup>F]FDG and [<sup>18</sup>F]FAPI PET/CT scans, the <sup>18</sup>F-FAPI uptake of liver and small intestine was significantly lower than the <sup>18</sup>F-FDG uptake in both the treated group and the control group (<italic>p</italic> &lt; 0.001).</p></sec><sec id="sec4"><title>Conclusion</title><p>This study suggests that milk consumption decreases physiological <sup>18</sup>F-FAPI uptake in the gallbladder, potentially enhancing the diagnostic accuracy for gallbladder cancer.</p></sec>