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CASE REPORT article

Front. Med.
Sec. Infectious Diseases: Pathogenesis and Therapy
Volume 11 - 2024 | doi: 10.3389/fmed.2024.1449637

A case of blood culture-negative Bartonella quintana endocarditis: Blood mNGS is an efficient method for early diagnosis

Provisionally accepted
Jun-fan Pu Jun-fan Pu 1,2Yan-Ling Zhou Yan-Ling Zhou 1*Min Deng Min Deng 1*Jing Wu Jing Wu 1*
  • 1 Department of Infectious Disease, The Dazu District People's Hospital, Chongqing, China
  • 2 The First Clinical College, Chongqing Medical University, Chongqing, China

The final, formatted version of the article will be published soon.

    Bartonella quintana is one of the main causes of blood culture-negative endocarditis, and routine blood culture and serological methods are difficult to achieve early diagnosis. We report a case of blood culture-negative Bartonella quintana endocarditis from southwestern Chongqing. The patient was a 67-year-old male scavenger who presented with heart failure without fever as the main clinical manifestation upon admission. He stated having had contact with stray cats in the past two months. The combination of clinical symptoms, echocardiography, and blood mNGS testing confirmed the infection of Bartonella quintana.A 67-year-old male scavenger from a rural area in western Chongqing presented to the Dazu District People's Hospital three weeks ago due to worsening edema, chest tightness, shortness of breath, and chest compression during daily activities. The patient had a history of bilateral lower extremity edema for ten years without obvious inducing factors. The edema was symmetrical and pitting, which usually improved after rest. The patient denied any history of chronic diseases such as

    Keywords: Bartonella quintana, Blood culture-negative, metagenomic nextgeneration sequencing, Infective endocarditis, cardiac failure

    Received: 07 Jul 2024; Accepted: 28 Oct 2024.

    Copyright: © 2024 Pu, Zhou, Deng and Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yan-Ling Zhou, Department of Infectious Disease, The Dazu District People's Hospital, Chongqing, 402360, China
    Min Deng, Department of Infectious Disease, The Dazu District People's Hospital, Chongqing, 402360, China
    Jing Wu, Department of Infectious Disease, The Dazu District People's Hospital, Chongqing, 402360, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.